| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
A rational combination of high hydrophobicity and acidic C-H hydrogens of carboranes afforded various artificial receptors. Among synthesized anion receptors, tricarborane derivative showed the property of chloride ion channel in chloride transport assay using liposome. Some tricarborane analogues showed a more potent association constant for chloride anion than the parent compound and a different selectivity for various anions. To understand hydrophobic interactions of carborane cages and apply carborane-containing compounds to medicinal drugs, the physicochemical properties about the complexation between cyclodextrins and various carborane derivatives are revealed.
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