Design, synthesis, and application of carborane-containing functional molecules based upon intermolecular interactions
| Project/Area Number |
21790116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
OHTA Kiminori 東北薬科大学, 薬学部, 講師 (90347906)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 医薬分子機能学 / ホウ素クラスター / 分子認識 / 生体関連化合物 / 機能性分子 / アニオンレセプター / イオンチャネル / 超分子 / 創薬化学 |
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| Research Abstract |
A rational combination of high hydrophobicity and acidic C-H hydrogens of carboranes afforded various artificial receptors. Among synthesized anion receptors, tricarborane derivative showed the property of chloride ion channel in chloride transport assay using liposome. Some tricarborane analogues showed a more potent association constant for chloride anion than the parent compound and a different selectivity for various anions. To understand hydrophobic interactions of carborane cages and apply carborane-containing compounds to medicinal drugs, the physicochemical properties about the complexation between cyclodextrins and various carborane derivatives are revealed.
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Report
(4 results)
Research Products
(80 results)
