| Project/Area Number |
21790119
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Tokyo University of Pharmacy and Life Science |
|---|
Principal Investigator |
HIKISHIMA Sadao Tokyo University of Pharmacy and Life Science, 薬学部, 助教 (70398816)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | ゲノム創薬 / siRNA / 薬学 / 有機化学 / 創薬化学 / ゲノム化学 / ホスフィン酸 / ラジカル反応 / RNA干渉 |
|---|
| Research Abstract |
For the production of stable siRNA molecules in vivo, We have designed novel modified siRNA molecules that contain phosphinate type dinucleotide derivatives at 3'-end. Though we examined various synthetic routes of phosphinate type dinucleotide derivatives, we could not find effective synthetic route.
|
