| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Nanomaterials are used frequently in microelectronics, cosmetics and sunscreen, and research for the development of nanomaterial-based drug delivery systems is promising. Interactions between nano-size materials and drugs that have therapeutic potential need investigating. Here, we investigated whether nano-size materials affect drugs-induced toxicity using inert polystyrene particles, nano-silicaand fullerrene particles, which have been widely used in industrial materials, carbon tertrachloride, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. The result, inert polystyrene particles and nano-silica particles induced liver injury by using together with the drugs. Our findings suggest that further evaluation on the interaction between nano-size materials and drugs is critical for the pharmaceutical application of nanotechnology.
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