Examination of nano-particles in mice with drugs or chemicals induced toxicity.

• Project/Area Number: 21790127
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental pharmacy
• Research Institution: Teikyo Heisei University
• Principal Investigator: ISODA Katsuhiro Teikyo Heisei University, 薬学部, 講師 (60423117)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 薬学 / 薬理学 / 衛生 / 環境 / 有害物質 / 有害化学物質 / 毒性学

Research Abstract

Nanomaterials are used frequently in microelectronics, cosmetics and sunscreen, and research for the development of nanomaterial-based drug delivery systems is promising. Interactions between nano-size materials and drugs that have therapeutic potential need investigating. Here, we investigated whether nano-size materials affect drugs-induced toxicity using inert polystyrene particles, nano-silicaand fullerrene particles, which have been widely used in industrial materials, carbon tertrachloride, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. The result, inert polystyrene particles and nano-silica particles induced liver injury by using together with the drugs. Our findings suggest that further evaluation on the interaction between nano-size materials and drugs is critical for the pharmaceutical application of nanotechnology.

Research Products

• [Journal Article] Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice. (2011)
  • Author(s): Li X., Kondoh M., Watari, A., Hasezaki T., Isoda K., Tsutsumi Y., Yagi K.
  • Journal Title: Pharmazie 66 Pages: 282-286
  • Peer Reviewed
• [Journal Article] Effect of surface charge on nano-sized silica particles-induced liver injury. (2011)
  • Author(s): Isoda K., Hasezaki T., Kondoh M., Tsutsumi Y., Yagi K.
  • Journal Title: Pharmazie 66 Pages: 278-181
  • Peer Reviewed
• [Journal Article] Influence of silica nanoparticles with a diameter 100nm induced liver injury (2011)
  • Author(s): Hasezaki T., Isoda K., Kondoh M., Tsutsumi Y., Yagi K.
  • Journal Title: Pharmazie in press.
  • Peer Reviewed
• [Journal Article] Effect of surface charge on nano-sized silica particles-induced liver injury (2011)
  • Author(s): Isoda K, Hasezaki T, Kondoh M, Tsutsumi Y, Yagi K
  • Journal Title: Pharmazie Volume: 4/2011
  • Peer Reviewed
• [Journal Article] Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice (2011)
  • Author(s): Li X, Kondoh M, Watari A, Hasezaki T, Isoda K, Tsutsumi Y, Yagi K
  • Journal Title: Pharmazie Volume: 4/2011
  • Peer Reviewed
• [Journal Article] Histological analysis of 70-nm silica particles-induced chronic toxicity in mice. (2009)
  • Author(s): Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
  • Journal Title: Eur.J.Pharm.Biopharm. 72 Pages: 626-629
  • Peer Reviewed
• [Journal Article] Silica nanoparticles as hepatotoxicants. (2009)
  • Author(s): Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
  • Journal Title: Eur.J.Pharm.Biopharm. 72 Pages: 496-501
  • Peer Reviewed
• [Journal Article] Influence of 70-nm silica particles in mice with cisplatin or paraquat-induced toxicity. (2009)
  • Author(s): Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
  • Journal Title: Pharmazie 64 Pages: 395-397
  • Peer Reviewed
• [Journal Article] Histological analysis of 70-nm silica particles-induced chronic toxicity in mice. (2009)
  • Author(s): Nishimori H., Kondoh M., Isoda_K., Tsunoda S., Tsutsumi Y., Yagi K.
  • Journal Title: Eur.J.Pharm.Biopharm. 72 Pages: 626-629
  • Peer Reviewed
• [Journal Article] Silica nanoparticles as hepatotoxicants. (2009)
  • Author(s): Nishimori H,, Kondoh M., Isoda_K., Tsunoda S., Tsutsumi Y., Yagi K
  • Journal Title: Eur.J.Pharm.Biopharm. 72 Pages: 496-501
  • Peer Reviewed
• [Journal Article] Influence of 70nm silica particles in mice with cisplatin or paraquat-induced toxicity. (2009)
  • Author(s): Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K
  • Journal Title: Pharmazie 64 Pages: 395-397
  • Peer Reviewed
• [Presentation] 粒径によるナノポリスチレンの薬物相互作用の解析 (2011)
  • Author(s): 清水芳実、磯田勝広、手塚絵梨子、羽澤一雄、林利彦、守隆夫、手塚雅勝、石田功
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 粒子径30nmと50nmのナノシリカの化学物質・薬物相互作用に関する検討 (2011)
  • Author(s): 手塚絵梨子、磯田勝広、清水芳実、羽澤一雄、矢野眞吾、土屋静子、手塚雅勝、石田功
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 粒径によるナノポリスチレンの薬物相互作用の解析 (2011)
  • Author(s): 清水芳実、磯田勝広、手塚絵梨子、羽澤一雄、林利彦、守隆夫、手塚雅勝、石田功
  • Organizer: 日本薬学会 第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 粒子径30nmと50nmのナノシリカの化学物質・薬物相互作用に関する検討 (2011)
  • Author(s): 手塚絵梨子、磯田勝広、清水芳実、羽澤一雄、矢野眞吾、土屋静子、手塚雅勝、石田功
  • Organizer: 日本薬学会 第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] ナノポリスチレン粒子と薬物・化学物質の相互作用に関する検討 (2010)
  • Author(s): 清水芳実、磯田勝広、永井優子、油布朋子、大野まき、手塚雅勝、石田功
  • Organizer: フォーラム2010衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京
  • Year and Date: 2010-09-09