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Examination of nano-particles in mice with drugs or chemicals induced toxicity.

Research Project

Project/Area Number 21790127
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental pharmacy
Research InstitutionTeikyo Heisei University

Principal Investigator

ISODA Katsuhiro  Teikyo Heisei University, 薬学部, 講師 (60423117)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords薬学 / 薬理学 / 衛生 / 環境 / 有害物質 / 有害化学物質 / 毒性学
Research Abstract

Nanomaterials are used frequently in microelectronics, cosmetics and sunscreen, and research for the development of nanomaterial-based drug delivery systems is promising. Interactions between nano-size materials and drugs that have therapeutic potential need investigating. Here, we investigated whether nano-size materials affect drugs-induced toxicity using inert polystyrene particles, nano-silicaand fullerrene particles, which have been widely used in industrial materials, carbon tertrachloride, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. The result, inert polystyrene particles and nano-silica particles induced liver injury by using together with the drugs. Our findings suggest that further evaluation on the interaction between nano-size materials and drugs is critical for the pharmaceutical application of nanotechnology.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (5 results)

  • [Journal Article] Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice.2011

    • Author(s)
      Li X., Kondoh M., Watari, A., Hasezaki T., Isoda K., Tsutsumi Y., Yagi K.
    • Journal Title

      Pharmazie 66

      Pages: 282-286

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of surface charge on nano-sized silica particles-induced liver injury.2011

    • Author(s)
      Isoda K., Hasezaki T., Kondoh M., Tsutsumi Y., Yagi K.
    • Journal Title

      Pharmazie 66

      Pages: 278-181

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of silica nanoparticles with a diameter 100nm induced liver injury2011

    • Author(s)
      Hasezaki T., Isoda K., Kondoh M., Tsutsumi Y., Yagi K.
    • Journal Title

      Pharmazie in press.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of surface charge on nano-sized silica particles-induced liver injury2011

    • Author(s)
      Isoda K, Hasezaki T, Kondoh M, Tsutsumi Y, Yagi K
    • Journal Title

      Pharmazie

      Volume: 4/2011

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice2011

    • Author(s)
      Li X, Kondoh M, Watari A, Hasezaki T, Isoda K, Tsutsumi Y, Yagi K
    • Journal Title

      Pharmazie

      Volume: 4/2011

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological analysis of 70-nm silica particles-induced chronic toxicity in mice.2009

    • Author(s)
      Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
    • Journal Title

      Eur.J.Pharm.Biopharm. 72

      Pages: 626-629

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Silica nanoparticles as hepatotoxicants.2009

    • Author(s)
      Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
    • Journal Title

      Eur.J.Pharm.Biopharm. 72

      Pages: 496-501

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of 70-nm silica particles in mice with cisplatin or paraquat-induced toxicity.2009

    • Author(s)
      Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K.
    • Journal Title

      Pharmazie 64

      Pages: 395-397

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histological analysis of 70-nm silica particles-induced chronic toxicity in mice.2009

    • Author(s)
      Nishimori H., Kondoh M., Isoda_K., Tsunoda S., Tsutsumi Y., Yagi K.
    • Journal Title

      Eur.J.Pharm.Biopharm. 72

      Pages: 626-629

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silica nanoparticles as hepatotoxicants.2009

    • Author(s)
      Nishimori H,, Kondoh M., Isoda_K., Tsunoda S., Tsutsumi Y., Yagi K
    • Journal Title

      Eur.J.Pharm.Biopharm. 72

      Pages: 496-501

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of 70nm silica particles in mice with cisplatin or paraquat-induced toxicity.2009

    • Author(s)
      Nishimori H., Kondoh M., Isoda K., Tsunoda S., Tsutsumi Y., Yagi K
    • Journal Title

      Pharmazie 64

      Pages: 395-397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 粒径によるナノポリスチレンの薬物相互作用の解析2011

    • Author(s)
      清水芳実、磯田勝広、手塚絵梨子、羽澤一雄、林利彦、守隆夫、手塚雅勝、石田功
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 粒子径30nmと50nmのナノシリカの化学物質・薬物相互作用に関する検討2011

    • Author(s)
      手塚絵梨子、磯田勝広、清水芳実、羽澤一雄、矢野眞吾、土屋静子、手塚雅勝、石田功
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 粒径によるナノポリスチレンの薬物相互作用の解析2011

    • Author(s)
      清水芳実、磯田勝広、手塚絵梨子、羽澤一雄、林利彦、守隆夫、手塚雅勝、石田功
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 粒子径30nmと50nmのナノシリカの化学物質・薬物相互作用に関する検討2011

    • Author(s)
      手塚絵梨子、磯田勝広、清水芳実、羽澤一雄、矢野眞吾、土屋静子、手塚雅勝、石田功
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナノポリスチレン粒子と薬物・化学物質の相互作用に関する検討2010

    • Author(s)
      清水芳実、磯田勝広、永井優子、油布朋子、大野まき、手塚雅勝、石田功
    • Organizer
      フォーラム2010衛生薬学・環境トキシコロジー
    • Place of Presentation
      東京
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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