| Project/Area Number |
21790128
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Sojo University (2010)
Kyushu University (2009) |
|---|
Principal Investigator |
ISHIDA Takumi Sojo University, 薬学部, 准教授 (10301342)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ダイオキシン / セレン結合性タンパク質 / 欠損マウス / 卵巣 / SeBP / TCDD / 毒性発現機構 / ガン |
|---|
| Research Abstract |
The biological roles of dioxin-inducible selenium-binding protein (SeBP) remain controversial. To address this issue, the SeBP-deficient mice were developed. The notable differences of phenotype and growth curve were not observed between wild-type and SeBP-deficient mice. However, the ovary weight in adult SeBP-deficient mice was significantly increased compared with that in adult wild-type mice. Thus, it is suggested that SeBP is one of suppressive factors of ovary tumor occurred with aging.
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