Studies on mechanism of adriamycin resistance induced by inhibition of endocytosis

• Project/Area Number: 21790138
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Tsutomu 東北大学, 大学院・薬学研究科, 助教 (00400474)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 制がん剤 / エンドサイトーシス / 癌 / 遺伝子

Research Abstract

In this study, we found that protein sorting system from endoplasmic reticulum to vacuole plays a key role in the mechanism of adriamycin resistance induced by inhibition of endocytosis

Research Products

• [Journal Article] Studies on molecular mechanism of toxicity of anticancer drags (2011)
  • Author(s): Takahashi T.
  • Journal Title: Yakugaku Zasshi Volume: 131(3) Pages: 355-358
  • Peer Reviewed
• [Journal Article] Studies on molecular mechanism of toxicity of anticancer drugs (2011)
  • Author(s): Takahashi T
  • Journal Title: Yakugaku Zasshi Volume: 131 Pages: 355-358
  • NAID: 130000678897
  • Peer Reviewed
• [Presentation] 酵母でのアドリアマイシン毒性軽減機構における細胞内小胞輸送の役割 (2010)
  • Author(s): 深澤ちさと、晴山聖子、廣瀬健一郎、高橋勉、永沼章
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 郡山市
  • Year and Date: 2010-10-24
• [Presentation] 酵母でのアドリアマイシン毒性軽減機構における細胞内小胞輸送の役割 (2010)
  • Author(s): 深澤ちさと, 晴山聖子, 廣瀬健一郎, 高橋勉, 永沼, 章
  • Organizer: 第49回日本薬学会東北支部大会
  • Place of Presentation: 奥羽大学
  • Year and Date: 2010-10-24
• [Presentation] Involvement of ER-to-golgi transport pathway in protection against adriamycin toxicity (2010)
  • Author(s): 深澤ちさと、高橋勉、永沼章
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-22
• [Presentation] HMG-CoA synthase高発現によるアドリアマイシン耐性獲得機構の解析 (2010)
  • Author(s): 増田拓朗、中島伸吾、高橋勉、永沼章
  • Organizer: フォーラム2010; 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京(星薬科大学)
  • Year and Date: 2010-09-09
• [Presentation] アドリアマイシン毒性軽減機構における脱ユビキチン化酵素Ubp3と小胞体-ゴルジ体間の小胞輸送経路との関係 (2010)
  • Author(s): 晴山聖子、深澤ちさと、廣瀬健一郎、高橋勉、永沼章
  • Organizer: 第37回日本トキシコロジー学会学術年会
  • Place of Presentation: 那覇市
  • Year and Date: 2010-06-16
• [Presentation] アドリアマイシン毒性軽減機構における脱ユビキチン化酵素Ubp3と小胞体-ゴルジ体間の小胞輸送経路との関係 (2010)
  • Author(s): 晴山聖子、深澤ちさと、廣瀬健一郎、高橋勉、永沼章
  • Organizer: 第37回日本トキシコロジー学会学術年会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2010-06-16
• [Presentation] 制がん剤感受性を規定する遺伝子の同定およびその作用機構の解析 (2010)
  • Author(s): 高橋勉
  • Organizer: 日本薬学会第130年会(シンポジウム)
  • Place of Presentation: 岡山市
  • Year and Date: 2010-03-30
• [Presentation] 制がん剤感受性を規定する遺伝子の同定およびその作用機構の解析 (2010)
  • Author(s): 高橋勉
  • Organizer: 日本薬学会 第130年会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-28
• [Presentation] Genome-wide screening for determinants of adriamycin sensitivity in Saccharomyces cerevisiae (2010)
  • Author(s): Ken-ishiro Hirose, Tsutomu Takahashi, Akira Naganuama
  • Organizer: 49th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Salt Lake City
  • Year and Date: 2010-03-09
• [Presentation] Role of protein phosphatase type 1 (PP1) in the protective mechanism against toxicity of Adriamycin (2010)
  • Author(s): Tsutomu Takahashi, Ken-ishiro Hirose, Akira Naganuama
  • Organizer: 49th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Salt Lake City
  • Year and Date: 2010-03-09
• [Presentation] Vacuolar protein sorting plays a major role in adnamaycin resistance induced by inhibition of early step in endocytosis in Saccharomyces cerevisiae (2009)
  • Author(s): 廣瀬健一郎、高橋勉、永沼章
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-01