Detection of BSEP mediated hepatotoxicity by using the intrahepatic bile acid imaging technique
Project/Area Number |
21790141
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
|
Research Institution | Chiba University |
Principal Investigator |
SEKINE Shuichi Chiba University, 大学院・薬学研究院, 助教 (70401007)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 薬学 / 薬剤反応性 / 蛋白質 / 放射線 / 薬剤反応生 |
Research Abstract |
Among 25 hepatotoxic compounds, we could newly detect 9 compounds which caused BSEP internalization. And also, we could confirm the increase of hepatotoxicity caused by the BSEP internalization-induced accumulation of bile acid in sandwiched rat hapatocytes.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats2010
Author(s)
Maeda, T., Miyazono, Y., Ito.K., Hamada, K., Sekine, S., Horie, T.
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Journal Title
Cancer.Chemother.Pharmacol. 65
Pages: 1117-1123
Related Report
Peer Reviewed
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[Journal Article] Posttranslational regulation of Abcc2 expression by SUMOylation system2009
Author(s)
Minami, S., Ito, K., Honma, M., Ikebuchi, Y., Anzai, N., Kanai, Y., Nishida, T., Tsukita, S., Sekine, S., Horie, T., Suzuki, H.
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Journal Title
Am.J.Physiol.Gastrointest.Liver.Physiol. 296
Pages: 406-413
Related Report
Peer Reviewed
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[Journal Article] Posttranslational regulation of Abcc2 expression by SUMO ylation system.2008
Author(s)
Minami S, Ito K, Honma M, Ikebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, Suzuki H.
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Journal Title
Am J Physiol Gastrointest Liver Physiol. 296(2)
Related Report
Peer Reviewed
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