Regulatory mechanisms of sterol transporters under pathophysiological conditions
Project/Area Number |
21790143
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | The University of Tokyo |
Principal Investigator |
TAKADA Tappei The University of Tokyo, 医学部附属病院, 助教 (90376468)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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Keywords | 発現制御 / 薬理学 / 生理学 / 脂質 / トランスポーター |
Research Abstract |
Niemann-Pick C1-like 1 (NPC1L1) is known to contribute to the cholesterol absorption in the small intestine and liver and is believed to be a pharmacological target of ezetimibe. As a result of the present study, we succeeded in the construction of human NPC1L1 promoter-driven adenovirus for the expression of human NPC1L1. In addition, it was demonstrated that L-FABP is involved in the positive regulation of the expression of NPC1L1 protein in a post-transcriptional manner. These results would be important to understand the relationship between the pathogenesis of obesity-related diseases and sterol transporters.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Itraconazole-induced cholestasis : involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4.2011
Author(s)
Yoshikado T, Takada T, Yamamoto T, Yamaji H, Ito K, Santa T, Yokota H, Yatomi Y, Yoshida H, Goto J, Tsuji S, Suzuki H.
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Journal Title
Mol Pharmacol. 79(2)
Pages: 241-250
Related Report
Peer Reviewed
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