Anti-tumor vaccine by the use of antigen targeting to lectins expressed on dendritic cells
| Project/Area Number |
21790144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
DENDA Kaori The University of Tokyo, 大学院・薬学系研究科, 助教 (00313122)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 樹状細胞 / レクチン / ターゲティング / 抗腫瘍ワクチン / 糖鎖 |
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| Research Abstract |
The subcutaneous injection of anti-MGL2 monoclonal antibodies successfully targeted antigens to the cells expressing MGL2 in mice. The antigens taken up through MGL2 were presented to antigen-specific CD4^+ T cells and led to an efficient antibody response. Since mouse MGL2 is thought to be a human MGL ortholog, these results are suggested to be able to apply to the development of novel vaccine.
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Report
(3 results)
Research Products
(53 results)
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[Journal Article] Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b) : Efficient uptake and presentation of glycosylated antigens by dendritic cells.2010
Author(s)
Denda-Nagai K, Aida S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T.
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Journal Title
J Biol Chem. 285
Pages: 19193-19204
Related Report
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[Journal Article] Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b) : Efficient uptake and presentation of glycosylated antigens by dendritic cells.2010
Author(s)
Denda-Nagai K, Aida S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T.
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Journal Title
J Biol Chem
Volume: 285
Pages: 19193-19204
Related Report
Peer Reviewed
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[Journal Article] Distribution and function of macrophage galactose-type C-type lectin 2(MGL2/CD301b): Efficient uptake and presentation of glycosylated antigens by dendritic cells2010
Author(s)
Denda-Nagai K, Aida, S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T.
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Journal Title
Related Report
Peer Reviewed
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