Quantitative Evaluation of the Effect of Influx/Efflux Transporters on Oral Drug Absorption
| Project/Area Number |
21790147
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
SHIRASAKA Yoshiyuki Kanazawa University, 薬学系, 助教 (60453833)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 薬物動態・代謝学 / 経口吸収 / 消化管 / トランスポーター / 薬学 / 薬物動態学 / 消化管吸収 / 薬物間相互作用 / 細胞・組織 / 生体分子 |
|---|
| Research Abstract |
In the present study, we aimed to clarify the contribution of OATP/Oatp and P-gp to the intestinal absorption of various drugs by means of various in vitro, in situ and in vivo experimental techniques. Trough the studies with various drugs including talinolol and pravastatin, pitavastatin, finally, this study revealed that OATP/Oatp is involved in intestinal drug absorption and the contribution of OATP/Oatp-mediated uptake was apparently attenuated by P-gp-mediated efflux in intestinal drug absorption process.
|
Report
(3 results)
Research Products
(29 results)
