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Quantitative Evaluation of the Effect of Influx/Efflux Transporters on Oral Drug Absorption

Research Project

Project/Area Number 21790147
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionKanazawa University

Principal Investigator

SHIRASAKA Yoshiyuki  Kanazawa University, 薬学系, 助教 (60453833)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords薬物動態・代謝学 / 経口吸収 / 消化管 / トランスポーター / 薬学 / 薬物動態学 / 消化管吸収 / 薬物間相互作用 / 細胞・組織 / 生体分子
Research Abstract

In the present study, we aimed to clarify the contribution of OATP/Oatp and P-gp to the intestinal absorption of various drugs by means of various in vitro, in situ and in vivo experimental techniques. Trough the studies with various drugs including talinolol and pravastatin, pitavastatin, finally, this study revealed that OATP/Oatp is involved in intestinal drug absorption and the contribution of OATP/Oatp-mediated uptake was apparently attenuated by P-gp-mediated efflux in intestinal drug absorption process.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2011 2010 2009

All Journal Article (15 results) (of which Peer Reviewed: 6 results) Presentation (14 results)

  • [Journal Article] Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.2011

    • Author(s)
      Shirasaka Y., Suzuki K.(他2名,1番目)
    • Journal Title

      J Pharm Sci. In press

    • Related Report
      2010 Final Research Report
  • [Journal Article] The effects of the SLCO2B1 c.1457C &gt ; T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.2011

    • Author(s)
      Imanaga J., Shirasaka Y.(他8名,7番目)
    • Journal Title

      Pharmacogenet Genomics. 21

      Pages: 84-93

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 12011

    • Author(s)
      Shirasaka Y., Suzuki K.(他3名,1番目)
    • Journal Title

      Drug Metab Pharmacokinet. 26

      Pages: 171-179

    • NAID

      130004463175

    • Related Report
      2010 Final Research Report
  • [Journal Article] The eftects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans2011

    • Author(s)
      Junko Imanaga
    • Journal Title

      Pharmacogenetics and genomics

      Volume: 21 Pages: 84-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 12011

    • Author(s)
      Yoshiyuki Shirasaka
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: (In press)

    • NAID

      130004463175

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem : involvement of human OATP family in apical membrane transport2011

    • Author(s)
      Kazuhiko Kato
    • Journal Title

      Molecular Pharmaceutics

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential effect of grapefruit juice on intestinal absorption of statins due to inhihition of organic anion transporting polypeptide and/or P-glycoprotein2011

    • Author(s)
      Yoshiyuki Shirasaka
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem : Involvement of Human OATP Family in Apical Membrane Transport.2010

    • Author(s)
      Kato K., Shirasaka Y.(他7名,2番目)
    • Journal Title

      Mol Pharm. 7

      Pages: 1747-1756

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide.2010

    • Author(s)
      Shirasaka Y., Suzuki K.(他2名,1番目)
    • Journal Title

      Pharm Res. 27

      Pages: 2141-2149

    • Related Report
      2010 Final Research Report
  • [Journal Article] Quantitation of talinolol in rat plasma by LC-MS-MS.2010

    • Author(s)
      Li Y., Shirasaka Y.(他2名,2番目)
    • Journal Title

      J Chromatogr Sci. 48

      Pages: 367-370

    • Related Report
      2010 Final Research Report
  • [Journal Article] Model analysis of the Concentration-dependent permeability of P-gp substrates.2010

    • Author(s)
      Tachibana T., Shirasaka Y.(他5名,5番目)
    • Journal Title

      Pharm Res. 27

      Pages: 442-446

    • NAID

      130005024251

    • Related Report
      2010 Final Research Report
  • [Journal Article] Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat.2010

    • Author(s)
      Shirasaka Y., Kuraoka E.(他4名,1番目)
    • Journal Title

      J Pharmacol Exp Ther. 332

      Pages: 181-189

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide2010

    • Author(s)
      Yoshiyuki Shirasaka
    • Journal Title

      Pharmaceutical Research

      Volume: 27 Pages: 2141-2149

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat2010

    • Author(s)
      Yoshiyuki Shirasaka
    • Journal Title

      The Journal of pharmacology and experimental th erapeutics 332

      Pages: 181-189

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concentration-dependent effect of naringin on intestinal absorption of ・1-adrenoceptor antagonist talinolol mediated by P-glycoprotein and organic anion transporting polypeptide (Oatp).2009

    • Author(s)
      Shirasaka Y., Li Y.(他6名,1番目)
    • Journal Title

      Pharm Res. 26

      Pages: 560-567

    • Related Report
      2010 Final Research Report
  • [Presentation] Influx/Effluxトランスポーターによる薬物の消化管吸収制御2011

    • Author(s)
      白坂善之, 中西猛夫, 玉井郁巳
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      東日本大震災のため誌上開催
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Influx/Effluxトランスポーターによる薬物の消化管吸収制御2011

    • Author(s)
      白坂善之
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      (東日本大震災のため誌上開催)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differential Interaction of Grapefruit Juice with Intestinal Absorption of HMG-CoA Reductase Inhibitors Pravastatin and Pitavastatin.2010

    • Author(s)
      Yoshiyuki Shirasaka, Kensuke Suzuki, Takeo Nakanishi, Ikumi Tamai.
    • Organizer
      GPEN 2010 (Globalization of Pharmaceutics Education Network
    • Place of Presentation
      University of North Carolina, Chapel Hill, NC (USA)
    • Year and Date
      2010-10-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Differential Interaction of Grapefruit Juice with Intestinal Absorption of HMG-CoA Reduetase Inhibitors Pravastatin and Pitavastatin2010

    • Author(s)
      Yoshiyuki Shirasaka
    • Organizer
      GPEN 2010 (Globatization of Pharmaceutics Eduction Network)
    • Place of Presentation
      University of North Carolina, Chapel Hill, NC, USA
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differential Transporter-Mediated Interaction of fruit juice with pravastatin and pitavastatin in rats.2010

    • Author(s)
      Yoshiyuki Shirasaka, Kensuke Suzuki, Takeo Nakanishi, Ikumi Tamai.
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Differential Transporter-Mediated Interaction of fruit juice with pravastatin and pitavastatin in rats2010

    • Author(s)
      Yoshiyuki Shirasaka
    • Organizer
      日本薬物動態学会第25回年会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] トランスポーターを介したHMG-CoA還元酵素阻害薬の消化管吸収動態2010

    • Author(s)
      白坂善之, 鈴木健介, 中西猛夫, 玉井郁巳
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島県郷土文化会館(徳島
    • Year and Date
      2010-05-12
    • Related Report
      2010 Final Research Report
  • [Presentation] トランスポーターを介したHMG-CoA還元酵素阻害薬の消化管吸収動態2010

    • Author(s)
      白坂善之
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんボール徳島県郷土文化会館(徳島県)
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] トランスポーターに起因した薬物の消化管吸収部位差に関する研究2009

    • Author(s)
      白坂善之, 松下高志, 中西猛夫,Peter Langguth, 玉井郁巳
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] トランスポーターに起因した薬物の消化管吸収部位差に関する研究2009

    • Author(s)
      白坂善之
    • Organizer
      日本薬物動態学会第24回年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 薬物の消化管吸収に及ぼすP糖蛋白質の影響とその評価に関する研究2009

    • Author(s)
      白坂善之
    • Organizer
      日本薬剤学会第34回製剤セミナー
    • Place of Presentation
      浜名湖ロイヤルホテル(静岡)
    • Year and Date
      2009-07-13
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] OATP/P-gpを介した薬物の消化管吸収動態とその種差2009

    • Author(s)
      白坂善之, 蔵岡えりか, 中西猛夫,Peter Langguth, 玉井郁巳
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡県コンベンションアーツセンター(静岡)
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] OATP-Mediated Intestinal Absorption of HMG-CoA Reductase Inhibitors in Rats2009

    • Author(s)
      Kensuke Suzuki, Yoshiyuki Shirasaka, Takeo Nakanishi, Ikumi Tamai
    • Organizer
      The 3^<rd> Asian Pacific ISSX Regional Meeting 2009
    • Place of Presentation
      The Imperial Queen's Park Hotel (Thailand)
    • Year and Date
      2009-05-11
    • Related Report
      2010 Final Research Report
  • [Presentation] OATP-MEDIATED INTESTINAL ABSORPTION OF HMG-COA REDUC TASE INHIBITORS IN RATS2009

    • Author(s)
      Kensuke Suzuki
    • Organizer
      The 3^<rd> Asian Pacific ISSX Regional Meeting 2009
    • Place of Presentation
      Bangkok, (Thailand)
    • Year and Date
      2009-05-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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