Involvement of human orphan carboxylesterase in drug metabolism and toxicity
Project/Area Number |
21790148
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Kanazawa University |
Principal Investigator |
FUKAMI Tatsuki Kanazawa University, 薬学系, 助教 (00532300)
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Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 薬物代謝 / 加水分解酵素 / 薬物毒性 / 加水分解 / 薬物誘発性肝障害 |
Research Abstract |
This study demonstrated that human arylacetamide deacetylase (AADAC) catalyzes the hydrolysis of flutamide, phenacetin, and rifamycins, which are reported to be associated with toxicity. In addition, it was found that the expression level of AADAC mRNA was decreased by bile acid through the repression of HNF4a activity by FXR-induced SHP.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Arylacetamide deacetylase is a determinant enzy e for the difference in hydrolase activities of phenacetin and acetaminophen.2010
Author(s)
Watanabe, A., Fukami, T., Takahashi, S., Kobayashi, Y., Nakagawa, N., Nakajima, M., Yokoi, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities.2010
Author(s)
Fukami, T., Takahashi, S., Nakagawa, N., Maruichi, T., Nakajima, M., Yokoi, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Human arylacetamide deacetylase is a principle enzyme in flutamide hydrolysis.2009
Author(s)
Watanabe, A., Fukami, T., Nakajima, M., Takamiya, M., Aoki, Y., Yokoi, T.
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Journal Title
Related Report
Peer Reviewed
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