Expression levels of human drug transporters in renal proxima tubules and regulation of their expression under kidney diseases
| Project/Area Number |
21790149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
MOTOHASHI Hideyuki Kyoto University, 医学研究科, 助教 (30359822)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | トランスポータ / 腎 / 薬学 / 腎臓 |
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| Research Abstract |
The kidney is the most important organ for the drug excretion. In the proximal tubules, drug transporters play the important roles for renal drug secretion. In this study, changes of renal drug transporters under renal diseases and correlation of regulator factors for renal diseases with drug transporter expression. The authors found that organic anion transporter decreased under acidosis condition and then that anionic drug secretion was decreased.
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Report
(3 results)
Research Products
(16 results)
