Exploration of the drug for metabolic disorders which related to ER stress-induced rupture of adipocytes homeostasis
| Project/Area Number |
21790153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
KAMIYA Tetsuro Gifu Pharmaceutical University, 薬学部, 助教 (60453057)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | EC-SOD / 小胞体ストレス / アディポネクチン / タプシガルギン / ツニカマイシン / eIF2α / ATF6 / XBP-1 / 小胞体ストレス制御因子 / salubrinal |
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| Research Abstract |
In this study, we investigated the expression of EC-SOD in 3T3-L1 adipocytes during ER stress conditions to explore the drug for metabolic disorders. We confirmed the reduction of EC-SOD by ER stress, but not of other SOD isozymes. Moreover, we speculated that the expression of EC-SOD was regulated by eIF2α signaling cascades. Overall, we suggested that the regulation of EC-SOD during ER stress conditions might lead to improve metabolic disorders.
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Report
(3 results)
Research Products
(23 results)
