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Inter-individual variations of flavin-containing monooxygenase 3 levels associated with multiple regulation factors

Research Project

Project/Area Number 21790160
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionShowa Pharmaceutical University

Principal Investigator

SHIMIZU Makiko  Showa Pharmaceutical University, 薬学部, 助教 (90307075)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
KeywordsFMO3 / trimethylaminuria / genetic polymorphism / Japanese / トリメチルアミン / トリメチルアミン尿症
Research Abstract

The flavin-containing monooxygenase 3 (FMO3) catalyzes the oxygenation of a wide variety of compounds containing sulfur or nitrogen atoms. FMO3 plays a role in processing some drugs, addictive chemical nicotine and diet-derived trimethylamine. Inter-individual variations of FMO3 are suggested to be co-regulated by trans-acting factors of FMO3 gene.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (13 results)

  • [Journal Article] Developmental variations in metabolic capacity of flavin-containing monooxygenase 3 in childhood.2011

    • Author(s)
      Shimizu, M., Denton, T., Kozono, M., Cashman, J.R., Leeder, J.S., Yamazaki, H.
    • Journal Title

      Bri.J.Clin.Pharmacol.

      Volume: 71 Pages: 585-591

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特異な体臭と代謝物分析:トリメチルアミン尿症を例として2010

    • Author(s)
      山崎浩史、清水万紀子
    • Journal Title

      ぶんせき 430

      Pages: 510-512

    • NAID

      10026787804

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.2010

    • Author(s)
      Taku Nagano, Makiko Shimizu, Kazuma Kiyotani, Tetsuya Kamataki, Ryohji Takano, Norie Murayama, Fumiaki Shono, Hiroshi Yamazaki
    • Journal Title

      Int.J.Environ.Res.Public Health 7

      Pages: 2953-2964

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling.2010

    • Author(s)
      Hiroshi Yamazaki, Kana Horiuchi, Ryohji Takano, Taku Nagano, Makiko Shimizu, Masato Kitajima, Norie Murayama, Fumiaki Shono
    • Journal Title

      Int.J.Environ.Res.Public Health 7

      Pages: 3406-3421

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.2010

    • Author(s)
      Nagano, T., Shimizu, M.Kiyotani, K., Kamataki, T., Takano, R., Murayama, N., Shono, F., H.Yamazaki.
    • Journal Title

      Int.J.Environ.Res.Public Health

      Volume: 7 Pages: 2953-2964

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特異な体臭と代謝物分析:トリメチルアミン尿症を例として2010

    • Author(s)
      山崎浩史、清水万紀子
    • Journal Title

      ぶんせき

      Volume: 430 Pages: 510-512

    • NAID

      10026787804

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects.2009

    • Author(s)
      Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
    • Journal Title

      Drug Metab Pharmacokinet. 24

      Pages: 549-552

    • NAID

      10027119731

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Individual Differences of Drug-metabolizing Enzymes as Determinants for the Metabolic Fate of Chemicals -A Study of Trimethylamine and Flavin-containing Monooxygenase 3-2009

    • Author(s)
      Makiko Shimizu
    • Journal Title

      Yakugaku Zasshi 129

      Pages: 1351-1356

    • NAID

      130000136124

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inter-individual variations of flavin-containing monooxygenase 3 in livers from Japanese : correlation with hepatic transcription factors.2009

    • Author(s)
      Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, Toshio Kumai, Shinichi Kobayashi, Fred P. Guengerich, Hiroshi Yamazaki
    • Journal Title

      Drug Metab. Pharmacokinet. 24

      Pages: 218-225

    • NAID

      10025723470

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bonitos with low content of malodorous trimethylamine as palliative care for self-reoorted Jananese trimethvlaminuria subiects.2009

    • Author(s)
      Shimizu M, Kozono M, Murayama N, Yamazaki H.
    • Journal Title

      Drug Metab Pharmacokinet. 24(6)

      Pages: 549-552

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies.2009

    • Author(s)
      Murayama N, Kaneko N, Horiuchi K, Ohyama K, Shimizu M, Ito K, Yamazaki H.
    • Journal Title

      Drug Metab Pharmacokinet. 24(4)

      Pages: 404-408

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Individual Differences of Drug-metabolizing Enzymes as Determinants for the Metabolic Fate of Chemicals A Study of Trimethylamine and Flavin-containing Monooxygenase 3-2009

    • Author(s)
      Shimizu M
    • Journal Title

      Yakugaku Zasshi 129

      Pages: 1351-1356

    • NAID

      130000136124

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人トリメチルアミン尿症の大規模実態調査2011

    • Author(s)
      清水万紀子、小林由布子、佐藤歩、徳元久乃、沼尾恵里、小園真里恵、村山典恵、山崎浩史
    • Organizer
      日本薬学会第131回年会(要旨集上にて発表)
    • Year and Date
      2011-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本人喫煙者の生体内ニコチン代謝物濃度の個人差2011

    • Author(s)
      永野卓、清水万紀子、清谷一馬、鎌滝哲也、松本史彦、村山典恵、山崎浩史
    • Organizer
      日本薬学会第131回年会(要旨集上にて発表)
    • Year and Date
      2011-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 成長に伴う酸素添加酵素フラビン含有モノオキシゲナーゼの個人内・個人間変動2010

    • Author(s)
      清水万紀子、小園真里恵、村山典恵、J.Steven Leeder、山崎浩史
    • Organizer
      第31回日本臨床薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Bonitos as palliative care for Japanese trimethylaminuria subjects2010

    • Author(s)
      Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
    • Organizer
      25th JSSX Annual Meeting
    • Place of Presentation
      埼玉
    • Year and Date
      2010-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Bonitos as palliative care for Japanese trimethylaminuria subjects.2010

    • Author(s)
      Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
    • Organizer
      25rd JSSX Annual Meeting
    • Place of Presentation
      さいたま市 大宮ソニックシティ
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成長に伴うフラビン含有モノオキシゲナーゼ3代謝効率の変化2010

    • Author(s)
      小園真里恵、清水万紀子、村山典恵、山崎浩史
    • Organizer
      第54回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 喫煙者血中濃度領域でのニコチン酸化的代謝に関与する薬物代謝酵素2010

    • Author(s)
      永野卓、清水万紀子、村山典恵、山崎浩史
    • Organizer
      第54回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本人ボランティアにおけるフラビン含有モノオキシゲナーゼ3の解析2010

    • Author(s)
      清水万紀子、青木悠佳、井萱翔、池田恵理奈、白石有紗、林祥子、村山典恵、山崎浩史
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] トリメチルアミン代謝に影響するフラビン含有モノオキシゲナーゼ3含量の変化2010

    • Author(s)
      小園真里恵、清水万紀子、村山典恵、山崎浩史
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] タバコ煙曝露量予測のための日本人喫煙者バイオモニタリング2010

    • Author(s)
      永野卓、清水万紀子、堀内佳奈、村山典恵、庄野文章、山崎浩史
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in a Japanese population2009

    • Author(s)
      Makiko Shimizu, Charles K.Allerston, Marie Kozono, Norie Murayama, Ian R. Phillips, Hiroshi Yamazaki
    • Organizer
      24th JSSX Annual Meeting
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in a Japanese population2009

    • Author(s)
      Shimizu M., Allerston C.K., Kozono M., Murayama N., Phillips I.R, Yamazaki H.
    • Organizer
      24rd JSSX Annual Meeting
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人におけるトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3の遺伝子変異の研究2009

    • Author(s)
      青木悠佳, 清水万紀子, 小園真里恵, 村山典恵, 山崎浩史
    • Organizer
      第53回日本薬学会関東支部大会
    • Place of Presentation
      埼玉
    • Year and Date
      2009-10-03
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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