Inter-individual variations of flavin-containing monooxygenase 3 levels associated with multiple regulation factors

• Project/Area Number: 21790160
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Showa Pharmaceutical University
• Principal Investigator: SHIMIZU Makiko Showa Pharmaceutical University, 薬学部, 助教 (90307075)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: FMO3 / trimethylaminuria / genetic polymorphism / Japanese / トリメチルアミン / トリメチルアミン尿症

Research Abstract

The flavin-containing monooxygenase 3 (FMO3) catalyzes the oxygenation of a wide variety of compounds containing sulfur or nitrogen atoms. FMO3 plays a role in processing some drugs, addictive chemical nicotine and diet-derived trimethylamine. Inter-individual variations of FMO3 are suggested to be co-regulated by trans-acting factors of FMO3 gene.

Research Products

• [Journal Article] Developmental variations in metabolic capacity of flavin-containing monooxygenase 3 in childhood. (2011)
  • Author(s): Shimizu, M., Denton, T., Kozono, M., Cashman, J.R., Leeder, J.S., Yamazaki, H.
  • Journal Title: Bri.J.Clin.Pharmacol. Volume: 71 Pages: 585-591
  • Peer Reviewed
• [Journal Article] 特異な体臭と代謝物分析:トリメチルアミン尿症を例として (2010)
  • Author(s): 山崎浩史、清水万紀子
  • Journal Title: ぶんせき 430 Pages: 510-512
  • NAID: 10026787804
  • Peer Reviewed
• [Journal Article] Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population. (2010)
  • Author(s): Taku Nagano, Makiko Shimizu, Kazuma Kiyotani, Tetsuya Kamataki, Ryohji Takano, Norie Murayama, Fumiaki Shono, Hiroshi Yamazaki
  • Journal Title: Int.J.Environ.Res.Public Health 7 Pages: 2953-2964
  • Peer Reviewed
• [Journal Article] Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling. (2010)
  • Author(s): Hiroshi Yamazaki, Kana Horiuchi, Ryohji Takano, Taku Nagano, Makiko Shimizu, Masato Kitajima, Norie Murayama, Fumiaki Shono
  • Journal Title: Int.J.Environ.Res.Public Health 7 Pages: 3406-3421
  • Peer Reviewed
• [Journal Article] Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population. (2010)
  • Author(s): Nagano, T., Shimizu, M.Kiyotani, K., Kamataki, T., Takano, R., Murayama, N., Shono, F., H.Yamazaki.
  • Journal Title: Int.J.Environ.Res.Public Health Volume: 7 Pages: 2953-2964
  • Peer Reviewed
• [Journal Article] 特異な体臭と代謝物分析:トリメチルアミン尿症を例として (2010)
  • Author(s): 山崎浩史、清水万紀子
  • Journal Title: ぶんせき Volume: 430 Pages: 510-512
  • NAID: 10026787804
• [Journal Article] Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects. (2009)
  • Author(s): Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
  • Journal Title: Drug Metab Pharmacokinet. 24 Pages: 549-552
  • NAID: 10027119731
  • Peer Reviewed
• [Journal Article] Individual Differences of Drug-metabolizing Enzymes as Determinants for the Metabolic Fate of Chemicals -A Study of Trimethylamine and Flavin-containing Monooxygenase 3- (2009)
  • Author(s): Makiko Shimizu
  • Journal Title: Yakugaku Zasshi 129 Pages: 1351-1356
  • NAID: 130000136124
  • Peer Reviewed
• [Journal Article] Inter-individual variations of flavin-containing monooxygenase 3 in livers from Japanese : correlation with hepatic transcription factors. (2009)
  • Author(s): Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, Toshio Kumai, Shinichi Kobayashi, Fred P. Guengerich, Hiroshi Yamazaki
  • Journal Title: Drug Metab. Pharmacokinet. 24 Pages: 218-225
  • NAID: 10025723470
  • Peer Reviewed
• [Journal Article] Bonitos with low content of malodorous trimethylamine as palliative care for self-reoorted Jananese trimethvlaminuria subiects. (2009)
  • Author(s): Shimizu M, Kozono M, Murayama N, Yamazaki H.
  • Journal Title: Drug Metab Pharmacokinet. 24(6) Pages: 549-552
  • Peer Reviewed
• [Journal Article] Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies. (2009)
  • Author(s): Murayama N, Kaneko N, Horiuchi K, Ohyama K, Shimizu M, Ito K, Yamazaki H.
  • Journal Title: Drug Metab Pharmacokinet. 24(4) Pages: 404-408
  • Peer Reviewed
• [Journal Article] Individual Differences of Drug-metabolizing Enzymes as Determinants for the Metabolic Fate of Chemicals A Study of Trimethylamine and Flavin-containing Monooxygenase 3- (2009)
  • Author(s): Shimizu M
  • Journal Title: Yakugaku Zasshi 129 Pages: 1351-1356
  • NAID: 130000136124
  • Peer Reviewed
• [Presentation] 日本人トリメチルアミン尿症の大規模実態調査 (2011)
  • Author(s): 清水万紀子、小林由布子、佐藤歩、徳元久乃、沼尾恵里、小園真里恵、村山典恵、山崎浩史
  • Organizer: 日本薬学会第131回年会(要旨集上にて発表)
  • Year and Date: 2011-03-05
• [Presentation] 日本人喫煙者の生体内ニコチン代謝物濃度の個人差 (2011)
  • Author(s): 永野卓、清水万紀子、清谷一馬、鎌滝哲也、松本史彦、村山典恵、山崎浩史
  • Organizer: 日本薬学会第131回年会(要旨集上にて発表)
  • Year and Date: 2011-03-05
• [Presentation] 成長に伴う酸素添加酵素フラビン含有モノオキシゲナーゼの個人内・個人間変動 (2010)
  • Author(s): 清水万紀子、小園真里恵、村山典恵、J.Steven Leeder、山崎浩史
  • Organizer: 第31回日本臨床薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2010-12-02
• [Presentation] Bonitos as palliative care for Japanese trimethylaminuria subjects (2010)
  • Author(s): Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
  • Organizer: 25th JSSX Annual Meeting
  • Place of Presentation: 埼玉
  • Year and Date: 2010-10-07
• [Presentation] Bonitos as palliative care for Japanese trimethylaminuria subjects. (2010)
  • Author(s): Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
  • Organizer: 25rd JSSX Annual Meeting
  • Place of Presentation: さいたま市 大宮ソニックシティ
  • Year and Date: 2010-10-07
• [Presentation] 成長に伴うフラビン含有モノオキシゲナーゼ3代謝効率の変化 (2010)
  • Author(s): 小園真里恵、清水万紀子、村山典恵、山崎浩史
  • Organizer: 第54回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-02
• [Presentation] 喫煙者血中濃度領域でのニコチン酸化的代謝に関与する薬物代謝酵素 (2010)
  • Author(s): 永野卓、清水万紀子、村山典恵、山崎浩史
  • Organizer: 第54回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-02
• [Presentation] 日本人ボランティアにおけるフラビン含有モノオキシゲナーゼ3の解析 (2010)
  • Author(s): 清水万紀子、青木悠佳、井萱翔、池田恵理奈、白石有紗、林祥子、村山典恵、山崎浩史
  • Organizer: 日本薬学会第130回年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] トリメチルアミン代謝に影響するフラビン含有モノオキシゲナーゼ3含量の変化 (2010)
  • Author(s): 小園真里恵、清水万紀子、村山典恵、山崎浩史
  • Organizer: 日本薬学会第130回年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] タバコ煙曝露量予測のための日本人喫煙者バイオモニタリング (2010)
  • Author(s): 永野卓、清水万紀子、堀内佳奈、村山典恵、庄野文章、山崎浩史
  • Organizer: 日本薬学会第130回年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in a Japanese population (2009)
  • Author(s): Makiko Shimizu, Charles K.Allerston, Marie Kozono, Norie Murayama, Ian R. Phillips, Hiroshi Yamazaki
  • Organizer: 24th JSSX Annual Meeting
  • Place of Presentation: 京都
  • Year and Date: 2009-11-27
• [Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in a Japanese population (2009)
  • Author(s): Shimizu M., Allerston C.K., Kozono M., Murayama N., Phillips I.R, Yamazaki H.
  • Organizer: 24rd JSSX Annual Meeting
  • Place of Presentation: 京都
  • Year and Date: 2009-11-27
• [Presentation] 日本人におけるトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3の遺伝子変異の研究 (2009)
  • Author(s): 青木悠佳, 清水万紀子, 小園真里恵, 村山典恵, 山崎浩史
  • Organizer: 第53回日本薬学会関東支部大会
  • Place of Presentation: 埼玉
  • Year and Date: 2009-10-03