| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
We tried development of novel tissue specific siRNA expression system for cancer gene therapy by VSV-G lentivirus vector. Therefore, we substituted sequence of CCR5-siRNA in endogenous microRNA for driving by tissue specific promoter (RNA polymerase type II). As a result, the siRNA expression system had not worked by RNA polymerase type II promoter. We need further study for the development of tissue specific siRNA expression system.
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