| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
An organic cation/proton antiporter is involved in the CNS acting cationic drug transport in the human blood-brain barrier model cells, suggesting that the proton antiporter mediates oxycodone transport into the brain across the blood-brain barrier in humans as well as rodents. Further, we showed that functions of organic cation-related transporters are able to be suppressed by small interfering RNA (siRNA). The siRNA screening method should be useful for the identification of the proton antiporter molecule which mediates blood-to-brain transport of oxycodone.
|
