| Project/Area Number |
21790165
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OZEKI Takeshi The Institute of Physical and Chemical Research, 遺伝情報解析チーム, 研究員 (30334402)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 遺伝子 / 発現制御 / 薬剤反応性 / 転写因子 |
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| Research Abstract |
In the present study, I investigated genetic polymorphisms of the HNF3 and HNF6 genes, and carried out an association study. Tag-SNPs containing the HNF3 and HNF6 genes were chosen by using a HapMap database, and performed an association study concerned with the appearance of the digestive organ toxicity by the doxorubicin. As a result, 2 SNPs located in the 5'-flanking region of the HNF3 gamma gene and a SNP in the 3'-downstream region of the HNF 6 beta gene showed significant associations with the digestive organ toxicity by the doxorubicin.
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