| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Eight genes, which were correlated negatively with the IC50 values for platinum derivatives, were extracted by a microarray analysis. In contrast, 48 genes were extracted, which showed the positive correlation with the IC50 values for platinum derivatives. The level of BRCA1/2 expression showed a positive correlation with the IC50 values for cisplatin, and that for 5-FU showed a positive correlation with the levels of MRP2 and MRP5 expression. In addition, proteome analysis indicated that 200 or 156 protein was expressed highly or low in the low-sensitive cells, respectively. Among them, the regulators for homeostasis of iron and for detoxification of heavy metal, were included.
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