| Project/Area Number |
21790170
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Hiroshima International University |
|---|
Principal Investigator |
TAYAMA Yoshitaka Hiroshima International University, 薬学部, 講師 (80389121)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 小児 / 胎児 / 新生児 / 薬物代謝 / 医薬品適正使用 / 薬物代謝酵素 / aldehyde oxidase / xanthine oxidase / 胎盤 |
|---|
| Research Abstract |
In the present study, we observed the developmental changes of drag metabolic enzyme, xanthine oxidase (XO) and aldehyde oxidase (AO) activity in postnatal rat liver. On the other hands, there were no developmental changes of rat placenta XO and AO activity during gestational period. Account for the change of placenta weight, their activity in whole body may change during gestational period. Threfore, we should make dose adjustment based on the developmental changes of drag metabolic enzyme activity.
|
