Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis.

• Project/Area Number: 21790178
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Kanazawa University
• Principal Investigator: ISHIMURA Akihiko Kanazawa University, がん研究所, 助教 (80375261)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 癌 / 遺伝子 / 発生・分化 / 細胞増殖

Research Abstract

In order to identify novel cancer-related genes, we have performed the retroviral insertional mutagenesis in mice, resulting in identification of Jmjd5, a histone demethylase. In this study, we have generated Jmjd5-deficient mice to investigate in vivo role of Jmjd5. Our results showed that Jmjd5 was involved in embryonic cell proliferation and that Cdkn1a might be one of Jmjd5 targets.

Research Products

• [Journal Article] The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase. (2010)
  • Author(s): Terashima M., Ishimura A., Yoshida M., Suzuki Y., Sugano S., Suzuki T.
  • Journal Title: Biochem.Biophys.Res.Commun. 399 Pages: 238-244
  • Peer Reviewed
• [Journal Article] The tumor suppressor Rb and its related Rb12 genes are regulated by Utx histone demethylase. (2010)
  • Author(s): Terashima M, Ishimura A, Yoshida M, Suzuki Y, Sugano S, Suzuki T
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 399 Pages: 238-244
  • Peer Reviewed
• [Journal Article] Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene. (2009)
  • Author(s): Ishimura A., Terashima M., Kimura H., Akagi K., Suzuki Y., Suganao S., Suzuki T.
  • Journal Title: Biochem.Biophys.Res.Commun. 389 Pages: 366-371
  • Peer Reviewed
• [Presentation] The physiological function of Jmjd5, a candidate cancer-related gene identified by retroviral insertional mutagenesis. (2011)
  • Author(s): Ishimura A, Minehata K, Terashima M, Hara T, Suzuki T.
  • Organizer: 平成22年度「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 琵琶湖ホテル(滋賀県)
  • Year and Date: 2011-02-03
• [Presentation] Functional analysis of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis. (2010)
  • Author(s): Ishimura A., Minehata K., Terashima M., Hara T., Suzuki T.
  • Organizer: 第32回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-12-10
• [Presentation] Functional analysis of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis. (2010)
  • Author(s): Ishimura A., Suzuki T.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-10-02
• [Presentation] The physiological role of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis. (2010)
  • Author(s): Ishimura A., Minehata K., Terashima M., Hara T., Suzuki T.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場、リーガロイヤルホテル大阪(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] The role of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis : Analysis of Jmjd5-deficient mice. (2010)
  • Author(s): Ishimura A., Minehata K., Terashima M., Hara T., Suzuki T.
  • Organizer: The Joint Symposium of the 5^<th> International Symposium of Institutes Network and the International Symposium Commemorating Inauguration of Kanazawa University Cancer Research Institute
  • Place of Presentation: KKRホテル金沢(石川県)
  • Year and Date: 2010-09-23
• [Presentation] レトロウイルス挿入変異法により同定された、新規がん関連遺伝子候補Jmjd5の機能解析 (2010)
  • Author(s): 石村昭彦、峯畑健一、寺島農、原孝彦、鈴木健之
  • Organizer: 第十回文部科学省特定領域研究「がん」5領域 若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科(長野県)
  • Year and Date: 2010-09-03
• [Presentation] The role of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis : Analysis of Jmjd5-deficient mice. (2010)
  • Author(s): 石村昭彦
  • Organizer: The Joint Symposium of the 5^<th> International Symposium of Institutes Network and the Tnternational Symposium Commemorating Inauguration of Kanazawa University Cancer Research Institute
  • Place of Presentation: KKRホテル金沢(石川県)
  • Year and Date: 2010-06-24
• [Presentation] Functional analysis of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis. (2009)
  • Author(s): Ishimura. A
  • Organizer: 第32回分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] Functional analysis of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis. (2009)
  • Author(s): Ishimura. A
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシファコ横浜(神奈川県)
  • Year and Date: 2009-10-02