| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
To elucidate a functional transformation of gastric parietal cells, we have newly developed an isolated rat gastric mucosa model whose parietal cells exhibited a reverting process from the active to resting state of acid secretion. Immunohistochemistry of H^+/K^+-ATPase demonstrated a progressive translocation of H^+/K^+-ATPase from the apical to the cytoplasmic region. In the reverting process, the apical membranes were internalized into the cytoplasm forming unique penta-laminar membranes which were labeled for autophagosome-marker LC3. This finding suggested an association of autophagy with the reverting process in the gastric parietal cell.
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