Analysis of the relationship between chemosensitive responses of the cardiovascular neurons and hypoxia

• Project/Area Number: 21790196
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: University of Tsukuba
• Principal Investigator: KOGANEZAWA Tadachika 筑波大学, 医学医療系, 助教 (80431691)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 循環調節 / 高血圧 / 交感神経 / 化学受容器 / 低酸素

Research Abstract

This project demonstrated that cardiovascular neurons have chemosensitivity into hypoxia. In order to investigate into the cause of hypertension, I also established the current clamp recording of the functionally identified cardiovascular neurons in the in situ arterially perfused preparation of rats. We also compared synaptic inputs into the cardiovascular neurons in normotensive and hypertensive rats. As a result, it is suggested that inhibitory inputs into the cardiovascular neurons are attenuated in the hypertensive rats compared to normotensive rats.

Research Products

• [Journal Article] Paton, Yoshitaka Oku A μ-opioidreceptor agonist DAMGO induces rapidbreathing in the arterially perfused insitu preparation of rat (2011)
  • Author(s): Tadachika Koganezawa, Yasumasa Okada, Naohito Terui, Julian F. R
  • Journal Title: Respiratory Physiology & Neurobiology Volume: 177(2) Pages: 207-211
  • Peer Reviewed
• [Journal Article] A μ-opioid receptor agonist DAMGO induces rapid breathing in the arterially perfused in situ preparation of rat (2011)
  • Author(s): Tadachika Koganezawa
  • Journal Title: Respiratory Physiology & Neurobiology Volume: 177(2) Pages: 207-211
  • Peer Reviewed
• [Presentation] ラット人工脳脊髄液灌流標本においてμ-オピオイド受容体作動薬DAMGOは頻呼吸を誘発する (2012)
  • Author(s): 小金澤禎史, 岡田泰昌, 照井直人, JulianF. R. Paton, 越久仁敬
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-31
• [Presentation] ウサギの防御反応および低酸素時におけるRVLMニューロンの異なる反応 (2011)
  • Author(s): 小金澤禎史
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] 交感神経活動亢進による高血圧の発生機構 (2011)
  • Author(s): 小金澤禎史, 照井直人
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-29
• [Presentation] 交感神経活動亢進による高血圧の発生機構 (2011)
  • Author(s): 小金澤禎史、照井直人
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2011-03-29
• [Presentation] 循環調節中枢における化学受容性応答 (2010)
  • Author(s): 小金澤禎史, 照井直人
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Presentation] Paton Whole cell patch recording from sympathetic pre-motor neurons in the rostral ventrolateral medulla (RVLM) of the neonatal rat in situ Society for Neuroscience (2009)
  • Author(s): Tadachika Koganezawa, Naohito Teruiand Julian F. R
  • Organizer: 39th Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 2009-09-19
• [Presentation] Whole cell patch recording from sympathetic pre-motor neurons in the rostral ventrolateral medulla(RVLM)of the neonatal rat in situ (2009)
  • Author(s): 小金澤禎史
  • Organizer: Society for Neuroscience 39th Annual Meeting
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2009-09-19
• [Presentation] Paton Whole cell patch recording of sympathetic pre-motor neurons in the medulla oblongata in the in situarterially perfused preparation of the neonatal rat (2009)
  • Author(s): Tadachika Koganezawa, Naohito Terui, Anthony E. Pickering, Julian F. R
  • Organizer: 6th Congress of The International Society for Autonomic Neuroscience
  • Place of Presentation: Sydney
• [Presentation] Whole cell patch recording of sympathetic pre-motor neurons in the medulla oblongata in the in situ arterially perfused preparation of the neonatal rat (2009)
  • Author(s): 小金澤禎史
  • Organizer: 6th Congress of the International Society for Autonomic Neuroscience
  • Place of Presentation: シドニー(豪州)