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Analysis of the relationship between chemosensitive responses of the cardiovascular neurons and hypoxia

Research Project

Project/Area Number 21790196
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionUniversity of Tsukuba

Principal Investigator

KOGANEZAWA Tadachika  筑波大学, 医学医療系, 助教 (80431691)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords循環調節 / 高血圧 / 交感神経 / 化学受容器 / 低酸素
Research Abstract

This project demonstrated that cardiovascular neurons have chemosensitivity into hypoxia. In order to investigate into the cause of hypertension, I also established the current clamp recording of the functionally identified cardiovascular neurons in the in situ arterially perfused preparation of rats. We also compared synaptic inputs into the cardiovascular neurons in normotensive and hypertensive rats. As a result, it is suggested that inhibitory inputs into the cardiovascular neurons are attenuated in the hypertensive rats compared to normotensive rats.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] Paton, Yoshitaka Oku A μ-opioidreceptor agonist DAMGO induces rapidbreathing in the arterially perfused insitu preparation of rat2011

    • Author(s)
      Tadachika Koganezawa, Yasumasa Okada, Naohito Terui, Julian F. R
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 177(2) Pages: 207-211

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A μ-opioid receptor agonist DAMGO induces rapid breathing in the arterially perfused in situ preparation of rat2011

    • Author(s)
      Tadachika Koganezawa
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 177(2) Pages: 207-211

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット人工脳脊髄液灌流標本においてμ-オピオイド受容体作動薬DAMGOは頻呼吸を誘発する2012

    • Author(s)
      小金澤禎史, 岡田泰昌, 照井直人, JulianF. R. Paton, 越久仁敬
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ウサギの防御反応および低酸素時におけるRVLMニューロンの異なる反応2011

    • Author(s)
      小金澤禎史
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 交感神経活動亢進による高血圧の発生機構2011

    • Author(s)
      小金澤禎史, 照井直人
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 交感神経活動亢進による高血圧の発生機構2011

    • Author(s)
      小金澤禎史、照井直人
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 循環調節中枢における化学受容性応答2010

    • Author(s)
      小金澤禎史, 照井直人
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Paton Whole cell patch recording from sympathetic pre-motor neurons in the rostral ventrolateral medulla (RVLM) of the neonatal rat in situ Society for Neuroscience2009

    • Author(s)
      Tadachika Koganezawa, Naohito Teruiand Julian F. R
    • Organizer
      39th Annual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2009-09-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Whole cell patch recording from sympathetic pre-motor neurons in the rostral ventrolateral medulla(RVLM)of the neonatal rat in situ2009

    • Author(s)
      小金澤禎史
    • Organizer
      Society for Neuroscience 39th Annual Meeting
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2009-09-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Paton Whole cell patch recording of sympathetic pre-motor neurons in the medulla oblongata in the in situarterially perfused preparation of the neonatal rat2009

    • Author(s)
      Tadachika Koganezawa, Naohito Terui, Anthony E. Pickering, Julian F. R
    • Organizer
      6th Congress of The International Society for Autonomic Neuroscience
    • Place of Presentation
      Sydney
    • Related Report
      2011 Final Research Report
  • [Presentation] Whole cell patch recording of sympathetic pre-motor neurons in the medulla oblongata in the in situ arterially perfused preparation of the neonatal rat2009

    • Author(s)
      小金澤禎史
    • Organizer
      6th Congress of the International Society for Autonomic Neuroscience
    • Place of Presentation
      シドニー(豪州)
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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