Analysis of the water-ion coupling ratio during ion-selective permeation through ion channels
| Project/Area Number |
21790198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Fukui |
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Principal Investigator |
IWAMOTO Masayuki University of Fukui, 医学部, 助教 (40452122)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 生体膜 / チャネル / 透過 |
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| Research Abstract |
In this study we succeeded in developing the improved method to measure the streaming potential that generates upon ion-selective permeation through ion channels. Extensive analysis of the streaming potential using KcsA potassium channel revealed that the number of water molecules accompanying with a permeating ion is modulated by ion species and its concentration. Based on the experimentally obtained water-ion coupling ratios, we presented here more dynamic and intuitive permeation model for the potassium channels than the conventional model.
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Report
(3 results)
Research Products
(22 results)
