Functional analysis of apolipoprotein E as a new regulator for angiogenesis
| Project/Area Number |
21790203
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Ehime University |
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Principal Investigator |
OHKUBO Nobutaka Ehime University, 大学院・医学系研究科, 講師 (10432791)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 細胞運動 / 形態形成 / 細胞間相互作用 / アポリポ蛋白E / 血管新生 / 血管内皮細胞増殖因子(VEGF) / がん / 角膜 |
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| Research Abstract |
Angiogenesis associated with growth of a cancer is well discribed, but its role in the progression of the cancer is unknown. we generated the APOE deficient mouse which cornea reduced the pigment by cross-mating and observed neovascularization on the cornea of this mouse. As a result of the observation, the sprouting of new capillaries were normal, but the extension were blocked and new capillaries were then regression in APOE deficient mice. This mechanism was independent of vascular endtherial growth factor (VEGF) role. Furthermore, the vascular permiability in new capillaries were decreased in APOE deficient mice. In conclusion, our data showed ApoE concerned with the extension of new capillaries by control on the vascular parmiability.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions.2009
Author(s)
Aoto, M., Shinzawa, K., Suzuki, Y., Ohkubo, N., Mitsuda, N., Tsujimoto Y
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Journal Title
FEBS Letter 583
Pages: 1611-1618
Related Report
Peer Reviewed
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