Regulation of p53 pathway and Tumor Growth by Novel Nucleolar Protein PICT1
| Project/Area Number |
21790204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kyushu University |
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Principal Investigator |
KAWAHARA Kohichi Kyushu University, 生体防御医学研究所・ゲノム腫瘍学分野, 助教 (00400482)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞増殖 / 細胞死 / p53経路 / 癌 / がん |
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| Research Abstract |
The tumor-suppressive MDM2-p53 intracellular signaling pathway is activated by cellular stress. Such stress includes DNA damage, which triggers the ATM-Chk2 and ATR-Chk1 cascades ; infection or oncogene activation, which induce t he p19ARF pathway ; and nucleolar stress, which initiates a cascade mediated by ribosomal proteins (RPs), particularly RPL5, RPL11, RPL23, and RPS7. These RPs are usually located in the nucleolus but are rapidly released into the nucleoplasm upon nucleolar stress, activating the MDM2-p53 pathway. However , it is unknown whether there are direct connections between p53-activating RP genes and cancer development in vivo, and which mechanism these RPs emplo y to translocate from the nucleolus to the nucleoplasm in response to stress . Using in vivo and in vitro experiments involving both human and murine tissues, we show that novel gene, Pict1, is a key regulator that acts thro ugh RP to control MDM2-p53 responses to nucleolar stress. In addition, Pict1 expression correlates with human colon cancer progression in human.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Regulation of the MDM2-P53Pathway and Tumor Growth by PICT1/GLTSCR2via Nucleolar RPL11
Author(s)
Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori, Akira Suzuki(These two authors contributed equally to this work as first authors)
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Journal Title
Related Report
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