Non-ionotropic functions of "ionotropic" glutamate receptor channels.

• Project/Area Number: 21790213
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Keio University
• Principal Investigator: KAKEGAWA Wataru Keio University, 医学部, 助教 (70383718)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: イオンチャネル / シナプス可塑性 / 記憶・学習 / 小脳 / 脳・神 / 生理学 / シナプス / デルタ2受容体

Research Abstract

To understand the non-ionotropic functions of ionotropic glutamate receptors (iGluRs), we analyzed the functions of the δ2 receptor which is a member of iGluRs. Interestingly, the external N-terminus and the internal C-terminus of the δ2 receptor regulated synapse formation and synaptic plasticity, respectively, in a channel property-independent manner. These results indicate that the δ2 receptors can be a good model to elucidate the whole pictures of iGluRs.

Research Products

• [Journal Article] D-Serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor. (2011)
  • Author(s): Wataru Kakegawa, Yurika Miyoshi, Kenji Hamase, Shinji Matsuda, Keiko Matsuda, Kazuhisa Kohda, Kyoichi Emi, Junko Motohashi, Ryuichi Konno, Kiyoshi Zaitsu, Michisuke Yuzaki
  • Journal Title: Nature Neuroscience 14 Pages: 603-611
  • Peer Reviewed
• [Journal Article] D-Serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor. (2011)
  • Author(s): W.Kakegawa, Y.Miyoshi, K.Hamase, S.Matsuda, K.Matsuda, K.Kohda, K.Emi, J.Motohashi, R.Konno, K.Zaitsu, M.Yuzaki
  • Journal Title: Nature Neuroscience Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] A new rapid protocol for eyeblink conditioning to assess cerebellar motor learning. (2011)
  • Author(s): K.Emi, K.Kohda, W.Kakegawa, S.Narumi, M.Yuzaki
  • Journal Title: Neurochemical Research Volume: 14 Pages: 603-611
  • Peer Reviewed
• [Journal Article] Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. (2010)
  • Author(s): Keiko Matsuda, Eriko Miura, Taisuke Miyazaki, Wataru Kakegawa, Kyoichi Emi, Sakae Narumi, Yugo Fukazawa, Aya Ito-Ishida, Tetsuro Kondo, Ryuichi Shigemoto, Masahiko Watanabe, Michisuke Yuzaki
  • Journal Title: Science 328 Pages: 363-368
  • Peer Reviewed
• [Journal Article] Reevaluation of neurodegeneration in lurcher mice : constitutive ion fluxes cause cell death with, not by, autophagy. (2010)
  • Author(s): Jun Nishiyama, Keiko Matsuda, Wataru Kakegawa, Nobuaki Yamada, Junko Motohashi, Noboru Mizushima, Michisuke Yuzaki
  • Journal Title: Journal of Neuroscience 30 Pages: 2177-2187
  • Peer Reviewed
• [Journal Article] Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer. (2010)
  • Author(s): K.Matsuda, E.Miura, T.Miyazaki, W.Kakegawa, K.Emi, S.Narumi, Y.Fukazawa, A.Ito-Ishida, T.Kondo, R.Shigemoto, M.Watanabe, M.Yuzaki
  • Journal Title: Science Volume: 328 Pages: 363-368
  • Peer Reviewed
• [Journal Article] The N-terminal domain of GluD2 (GluRδ2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo. (2009)
  • Author(s): Wataru Kakegawa, Taisuke Miyazaki, Kazuhisa Kohda, Keiko Matsuda, Kyoichi Emi, Junko Motohashi, Masahiko Watanabe, Michisuke Yuzaki
  • Journal Title: Journal of Neuroscience 29 Pages: 5738-5748
  • Peer Reviewed
• [Journal Article] The N-terminal domain of GluD2 (GluRδ2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo. (2009)
  • Author(s): Kakegawa, W., Miyazaki, T., Kohda, K., Matsuda, K., Emi, K., Motohashi, J., Watanabe, M., Yuzaki, M
  • Journal Title: The Journal of Neuroscience 29 Pages: 5738-5748
  • Peer Reviewed
• [Journal Article] A new rapid protocol for eyeblink conditioning to assess cerebellar motor learning.
  • Author(s): Kyoichi Emi, Kazuhisa Kohda, Wataru Kakegawa, Sakae Narumi, Michisuke Yuzaki
  • Journal Title: Neurochemical Research 印刷中
  • Peer Reviewed
• [Presentation] Endogenous D-serine controls cerebellar LTD and motor performance through GluD2. (2010)
  • Author(s): Wataru Kakegawa, Yurika Miyoshi, Kenji Hamase, Kiyoshi Zaitsu, Michisuke Yuzaki
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Presentation] Differential regulation of synapse formation and plasticity by GluRδ2 in the cerebellum. (2009)
  • Author(s): Wataru Kakegawa, Taisuke Miyazaki, Kyoichi Emi, Keiko Matsuda, Kazuhisa Kohda, Junko Motohashi, Masayoshi Mishina, Masahiko Watanabe, Michisuke Yuzaki
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] Differential regulation of synapse formation and plasticity by GluRδ2 in the cerebellum (2009)
  • Author(s): Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Watanabe, M., Yuzaki, M.
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Book] 生体の科学:シナプスをめぐるシグナリング(Delta2受容体) (2010)
  • Author(s): 幸田和久, 掛川渉, 柚崎通介
  • Publisher: 医学書院
• [Remarks] ホームページ等
  • URL: http://www.yuzaki-lab.org/
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/physiol/yuzaki/index.htm