Research on the activation mechanism of volume-sensitive ion channels in neurons and glia
| Project/Area Number |
21790216
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
AKITA Tenpei National Institute for Physiological Sciences, 細胞器官研究系, 特任助教 (00522202)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 細胞容積調節 / イオンチャネル / アストログリア / ブラジキニン / カルシウムイオン / カルシウムナノドメイン / 活性酸素種 / 細胞間情報伝達 / Ca^<2+>ナノドメイン / ATP / グルタミン酸 |
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| Research Abstract |
We investigated the activation mechanism of one of the most influential regulators of cell volume, shape and fate, the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system. Within this research period, we have found especially a fundamental mechanism of VSOR channel activation in the major glial cells, astrocytes, which would operate even in response to a minute damage happening in surrounding tissues with high fidelity and certainty.
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Report
(3 results)
Research Products
(13 results)
