Screening of compounds for p53 dependent or independent cell death
| Project/Area Number |
21790217
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
TATUDA Daisuke 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員 (20442569)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | がん / p53 / 細胞死 / Mdm2 / geraniin / eugeniin / ゲンノショウコ / 新規化合物 / 分子標的 / スクリーニング / ユビキチン-プロテアソーム |
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| Research Abstract |
To search for new anti-tumor compounds, we screened new compounds for p53 dependent cell death. As a result of screenings, we identified ellagitannins from the plant extracta and 5 new natural products from the microbial metabolite. Geraniin and eugeniin, a member of ellagitannins, suppressed tumor growth of osteosarcoma cells in a xenograft model.
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Report
(5 results)
Research Products
(29 results)
