| Project/Area Number |
21790218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
IWAWAKI Takao The Institute of Physical and Chemical Research, 中野生体膜研究室, 客員主管研究員 (50342754)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 小胞体ストレス / 血管新生 / 胎盤 / 膵臓 / 糖尿病 / 唾液腺 / タンパク質品質管理 / 小胞体ストレス応答 / インスリン / 抗体産生 / 動脈硬化 / RNA / 妊娠 / 小胞体シャペロン / RNase |
|---|
| Research Abstract |
Endoplasmic reticylum (ER) stress has actively been studied at the intracellular level so far. In this research, the purpose is to study the role of ER stress response at the intercellular level and in vivo level. By using in vivo stress imaging and gene targeting technologies, we found that ER stress responsive molecules are essential for the function of the placenta, the salivary gland, and the pancreas. Especially we performed detail investigation for activation of vascular endothelial growth factor in the placenta.
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