The identification of a novel mechanism of osteoclast differentiation that is calcium oscillation-independent osteoclastogenesis
| Project/Area Number |
21790220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KURODA Yukiko The Institute of Physical and Chemical Research, 発生神経生物研究チーム, 基礎科学特別研究員 (70455343)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分化 / 破骨細胞 / カルシウムオシリーション / 細胞融合 / シグナル伝達 / イノシトール三リン酸(IP3) / カルシウムオシレーション / 骨 / イノシトール3リン酸 (IP3) / IRBIT |
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| Research Abstract |
By analysis of osteoclasts derived from IRBIT knockout mice, we found that the number of RANKL-induced Ca^<2+> oscillation positive cells was increased in IRBIT knockout mononuclear osteoclasts and that IRBIT knockout cells enhanced cell-cell fusion step during osteoclastogenesis as compared with wild-type cells. These results indicate that IRBIT negatively regulates IP_3R-mediated Ca^<2+> signaling and cell-cell fusion step during osteoclast differentiation.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Inositol 1, 4, 5-triphosphate receptor-binding protein released with inositol 1, 4, 5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation -dependent manner and inhibits polyadenylation.2009
Author(s)
Kiefer H, Mizutani A, Iemura S, Natsume T, Ando H, Kuroda Y, Mikoshiba K.
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Journal Title
J Biol Chem. 284(16)
Pages: 10694-10705
Related Report
Peer Reviewed
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