Effect of neurogenesis and apoptosis on DHA-improved memory function
Project/Area Number |
21790226
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
Research Institution | Shimane University |
Principal Investigator |
KATAKURA Masanori Shimane University, 医学部, 助教 (40383179)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 栄養生理学 / ドコサヘキサエン酸 / 神経新生 / 記憶 / 学習能力 / 神経幹細胞 / 細胞周期 / 脂質 |
Research Abstract |
We hypothesized that neurogenesis may involve in Docosahexaenoic acid (DHA) -enhanced learning and memory ability. In this study we tried to understand effect of memory formation on apoptosis of neural stem cells (NSCs). The numbers of newborn cells in the hippocampus were increased and improved learning ability by treatment of DHA for 8-weeks orally. These results indicate that DHA enhances neuronal differentiation from NSCs but also enhances proliferation of NSCs.
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Report
(3 results)
Research Products
(46 results)