Mechanism of remodeling and functional compensation after stroke in intact hemisphere

• Project/Area Number: 21790233
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Gunma University
• Principal Investigator: TAKATSURU Yusuke Gunma University, 大学院・医学系研究科, 助教 (30446265)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 2光子顕微鏡 / 脳梗塞 / In vivo imaging / In vivo microdialysis / In vivo電気生理記録 / 体性感覚 / 局所脳梗塞モデル / 2光子励起レーザー顕微鏡 / Thy1-EYFP(H-line)マウス

Research Abstract

Remodeling and/or synapse plasticity is increased at 1^<st> week after stroke in intact hemisphere. In contrast, recovery of general behavior is delay compared with those in simple somatosensory function. During the remodeling, glutamine, glysine and dopamine seems to be play an important role. Application of haloperidol at 2-4 days after stroke prolongs the recovery.

Research Products

• [Journal Article] Unilateral infarction of the visual cortex (VC) induced an increase in dendritic spine turnover in contralateral (2011)
  • Author(s): Takatsuru, Y., Koibuchi, N., Nabekura, J.
  • Journal Title: VC.Neurosci.Lett. 488 Pages: 97-100
  • Peer Reviewed
• [Journal Article] Unilateral infarction of the visual cortex (VC) induced an increase in dendritic spine turnover in contralateral VC. (2011)
  • Author(s): Takatsuru, Y., Koibuchi, N., Nabekura, J.
  • Journal Title: Neuroscience Letters Volume: 488 Pages: 97-100
  • Peer Reviewed
• [Journal Article] 障害後のシナプス再生および神経回路の再編 (2010)
  • Author(s): 鍋倉淳一、江藤圭、高鶴裕介
  • Journal Title: Clin.Neurosci. 28 Pages: 865-868
• [Journal Article] 障害後のシナプス再生および神経回路の再編 (2010)
  • Author(s): 鍋倉淳一、江藤圭、高鶴裕介
  • Journal Title: Clin.Neurosci. Volume: 28 Pages: 865-868
• [Journal Article] Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction. (2009)
  • Author(s): Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Nabekura, J.
  • Journal Title: J.Neurosci. 29(32) Pages: 10081-10086
  • Peer Reviewed
• [Journal Article] Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction (2009)
  • Author(s): Y.Takatsuru, D.Fukumoto, M.Yoshitomo, T.Nemoto, H.Tsukada, J.Nabekura
  • Journal Title: Journal of Neuroscience 29 Pages: 10081-10086
  • Peer Reviewed
• [Presentation] 局所脳梗塞回復期の健常半球における神経回路再編機構 (2011)
  • Author(s): 高鶴裕介、鯉淵典之、鍋倉淳一
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜(震災のため誌上開催)
  • Year and Date: 2011-03-28
• [Presentation] Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction (2011)
  • Author(s): Yusuke Takatsuru, Noriyuki Koibuchi, Junichi Nabekura.
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜(神奈川)(震災のため誌上開催)
  • Year and Date: 2011-03-28
• [Presentation] 体性感覚野梗塞後の機能代償における健常半球の神経回路再編成 (2010)
  • Author(s): 高鶴裕介、鯉淵典之、鍋倉淳一
  • Organizer: 第243回生理学東京談話会
  • Place of Presentation: 川越
  • Year and Date: 2010-12-04
• [Presentation] 体性感覚野梗塞後の機能代償における健常半球の神経回路再編成 (2010)
  • Author(s): 高鶴裕介、鯉淵典之、鍋倉淳一
  • Organizer: 第243回生理学東京談話会
  • Place of Presentation: 川越(埼玉)
  • Year and Date: 2010-12-04
• [Presentation] 局所脳梗塞からの機能代償における健常半球の神経再編成 (2010)
  • Author(s): 高鶴裕介、鯉淵典之
  • Organizer: 第57回北関東医学会総会
  • Place of Presentation: 群馬
  • Year and Date: 2010-10-07
• [Presentation] 局所脳梗塞からの機能代償における健常半球の神経再編成 (2010)
  • Author(s): 高鶴裕介、鯉淵典之
  • Organizer: 第57回北関東医学会総会
  • Place of Presentation: 前橋(群馬)
  • Year and Date: 2010-10-07
• [Presentation] Contribution ofcontralateral hemisphere on functional recovery from focal infarction in somatosensory cortex. (2010)
  • Author(s): Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Koibuchi, N., Nabekura, J.
  • Organizer: 7th FENS
  • Place of Presentation: Nederland, Amsterdam
  • Year and Date: 2010-07-06
• [Presentation] Contribution of contralateral hemisphere on functional recovery from focal infarction in somatosensory cortex. (2010)
  • Author(s): Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Koibuchi, N.Nabekura, J.
  • Organizer: 7^<th> FENS
  • Place of Presentation: アムステルダム(オランダ)
  • Year and Date: 2010-07-06
• [Presentation] The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex. (2009)
  • Author(s): Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Nabekura, J.
  • Organizer: IUPS2009
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex (2009)
  • Author(s): Y.Takatsuru, D.Fukumoto, M.Yoshitomo, T.Nemoto, H.Tsukada, J.Nabekura
  • Organizer: IUPS2010
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30