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Development of peptide molecules that can regulate melanoma stem cells

Research Project

Project/Area Number 21790238
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionChiba University

Principal Investigator

SUGANAMI Akiko  千葉大学, 大学院・医学研究院, 特任研究員 (10527922)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords創薬 / ゲノム薬理学 / 悪性黒色腫 / 癌幹細胞 / IL-10 / ペプチド分子標的薬 / コンピュータ・シミュレーション / 細胞内局在
Research Abstract

The malignant melanoma is a kind of the skin cancer with high malignancy. Furthermore, it is easy to metastasize to brain, lung and liver. In this study, I utilized the in silico molecular evolution system. It is a computer simulation system that was developed in our laboratory for the creation of peptide drugs. I already created some peptide molecules that is expected to be effective for the treatment of the malignant melanoma. In addition, I constructed a new drug delivery system (DDS) that employed liposome as a main component.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2011 Other

All Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/bioinfor/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/bioinfor/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] リポソーム複合体2011

    • Inventor(s)
      菅波晃子
    • Industrial Property Rights Holder
      鳥取大学, 千葉大学
    • Industrial Property Number
      2011-223273
    • Filing Date
      2011-10-07
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] リポソーム複合体2011

    • Inventor(s)
      菅波晃子, その他
    • Industrial Property Rights Holder
      鳥取大学 千葉大学
    • Industrial Property Number
      2011-223273
    • Filing Date
      2011-10-07
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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