Mechanism of protective effects of calcitonin gene-related peptide on liver injury

• Project/Area Number: 21790240
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Shinshu University
• Principal Investigator: KAMIYOSHI Akiko Shinshu University, 医学系研究科, 助教 (10397309)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 生理活性物質 / 肝臓学

Research Abstract

α-Calcitonin gene-related peptide (αCGRP) is a pleiotropic peptide including vasodilating effects. By analysis of αCGRP knockout (αCGRP-/-) mice, endogenous αCGRP showed to exert a hepatoprotective effect, on concanavalin A (Con A)-induced acute hepatitis and chronic hepatitis model. In addition, administration of exogenous αCGRP has a hepatoprotective effect. αCGRP could be a useful therapeutic target for the treatment of hepatitis.

Research Products

• [Journal Article] Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver. (2010)
  • Author(s): Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T.
  • Journal Title: Peptides 31(5) Pages: 865-871
  • NAID: 120007110397
  • Peer Reviewed
• [Journal Article] Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver. (2010)
  • Author(s): Iinuma N, et al.
  • Journal Title: Peptides Volume: 31(5) Pages: 865-871
  • Peer Reviewed
• [Journal Article] Endogenous α-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A. (2009)
  • Author(s): Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T.
  • Journal Title: Liver Int 29(5) Pages: 642-649
  • Peer Reviewed
• [Journal Article] Endogenous α-calitonin gene-releted peptide mitigetee liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A (2009)
  • Author(s): Kamiyoshi A
  • Journal Title: Liver International 29(5) Pages: 642-649
  • Peer Reviewed
• [Presentation] ES細胞胚様体分化系を用いた肝類洞内皮細胞分化誘導と高次肝様構造構築 (2011)
  • Author(s): 荒居琢磨、桜井敬之、神吉昭子、新藤優佳、小山晃英、吉沢隆浩、植竹龍一、家里康弘、沖村綾乃、山内啓弘、Yang Lei、田中愛、河手久香、小川真一郎、宮川眞一、新藤隆行
  • Organizer: 第40回日本心脈管作動物質学会
  • Place of Presentation: 香川
  • Year and Date: 2011-02-04
• [Presentation] アドレノメデュリン-RAMP2系による心臓エネルギー代謝制御と恒常性維持 (2011)
  • Author(s): 吉沢隆浩、桜井敬之、神吉昭子、河手久香、新藤優佳、荒居琢磨、小山晃英、家里康弘、Yang Lei、植竹龍一、山内啓弘、沖村綾乃、田中愛、川上速人、中西広樹、田口良、中西豪、新藤隆行
  • Organizer: 第40回日本心脈管作動物質学会
  • Place of Presentation: 香川
  • Year and Date: 2011-02-04
• [Presentation] 血管内皮細胞のアドレノメデュリン-RAMP2システムによる血管恒常性維持機構 (2011)
  • Author(s): 小山晃英、桜井敬之、神吉昭子、新藤優佳、河手久香、荒居琢磨、家里康弘、吉沢隆浩、Yang Lei、植竹龍一、沖村綾乃、山内啓弘、田中愛、新藤隆行
  • Organizer: 第40回日本心脈管作動物質学会
  • Place of Presentation: 香川
  • Year and Date: 2011-02-04
• [Presentation] 血管内皮細胞におけるアドレノメデュリン-RAMP2システムの役割 (2010)
  • Author(s): 小山晃英、桜井敬之、神吉昭子、荒居琢磨、新藤優佳、吉沢隆浩、Yang Lei、植竹龍一、沖村綾乃、山内啓弘、田中愛、新藤隆行
  • Organizer: 第18回日本血管生物医学会 大阪医学会2010年12月1日
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] Shindo T AM-RAMP2 System, as a Novel Regulator of Cardiac Homeostasis (2010)
  • Author(s): Yoshizawa T, Sakurai T, Kamiyoshi A,Shindo Y, Kawate H, Koyama T, Kawakami H,Nakanishi H, Taguchi R
  • Organizer: The 14th Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism (CVEM)
  • Place of Presentation: 奈良
  • Year and Date: 2010-03-31
• [Presentation] 発生および老化におけるアドレノメデュリン-RAMP2系の血管恒常性維持機構 (2010)
  • Author(s): 小山晃英、桜井敬之、神吉昭子、吉沢隆浩、新藤優佳、川上速人、新藤隆行
  • Organizer: 第83回日本内分泌学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-25
• [Presentation] アドレノメデュリン-RAMP2システムによる血管・リンパ管新生と恒常性維持機構の解明 (2009)
  • Author(s): 小山晃英、桜井敬之、神吉昭子、吉沢隆浩、新藤優佳、川上速人、新藤隆行
  • Organizer: 第17回日本血管生物医学会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-08
• [Presentation] アドレノメデュリン-RAMP2システムによる心保護作用 (2009)
  • Author(s): 吉沢隆浩、桜井敬之、神吉昭子、小山晃英、新藤優佳、川上速人、新藤隆行
  • Organizer: 第32回日本高血圧学会
  • Place of Presentation: 大津
  • Year and Date: 2009-10-02