Clarification of insulin/IGF-I receptor signal expression mechanism
| Project/Area Number |
21790244
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
NEMOTO Takayuki University of Miyazaki, 医学部, 助教 (90506833)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | インスリン受容体 / IGF-I受容体 / IRS / GSK-3β / mTOR / tau / Nav1.7 / Na_v1.7 / Insulin receptor substrate-1 / -2 / Glycogen synthase kinase-3β |
|---|
| Research Abstract |
We clarified (1) IRS expression by Hsp90 ; (2) up-regulation of Nav1.7 by GSK-3β inhibition ; (3) IGF-I-induced homologous regulation of IGF-I receptor expression via GSK-3βand mTOR ; and (4) decrease of phosphorylated tau via GSK-3β inhibition by Na+ influx-induced activations of PI3K-Akt and PKC-α-ERK/p38 pathways.
|
Report
(3 results)
Research Products
(42 results)
