Analysis of the mechanism of photoreceptor cell death induced by retinitis pigmentosa in order to develop the new therapy.
| Project/Area Number |
21790249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳神経疾患 / 薬理学 |
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| Research Abstract |
Mutation in phosphodiesterase 6 genes(PDE6) causes retinitis pigmentosa(RP). The present study demonstrated that apocynin, a NADPH oxidase inhibitor, and nilvadipine, a Ca^<2+> channel blocker with an anti-oxidant effect, protect against photoreceptor cell death in the nmf363 mouse, which has a mutation in Pda6a, and the nmf137 mouse, which has a mutation in Pde6b, respectively. Therefore, these drugs may be able to use for treatment of RP patients.
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Report
(4 results)
Research Products
(37 results)
