Search of regulatory factors in neural glutathione concentration

Research Project

Project/Area Number	21790251
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General pharmacology
Research Institution	Teikyo University
Principal Investigator	WATABE Masahiko Teikyo University, 医学部, 講師 (90301788)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	脳・神経 / 脳神経疾患 / ストレス
Research Abstract	Glutathione is an essential reductant which protects cells and is reduced in neurodegenerative disorders such as a Parkinson's disease. Neurons rely mainly on extracellular cysteine for glutathione synthesis and a cysteine transporter termed excitatory amino acid carrier-1 (EAAC1). I previously showed GTRAP3-18 (glutamate transport associated protein for EAAC1) to interact with EAAC1 and thereby regulate neuronal glutathione levels. In this time, I indicated the phosphorylation of GTRAP3-18, which is a key of information to search regulatory factors in neural glutathione concentration.

Report

(3 results)