Mechanism of vascular dysfunction induced by the interaction of CRP and LOX-1

• Project/Area Number: 21790259
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: FUJITA Yoshiko 独立行政法人国立循環器病研究センター, 血管生理学部, 研究員 (30416218)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 心血管 / 血液 / 動脈硬化 / LOX-1 / 虚血性心疾患

Research Abstract

(No Summary)

Research Products

• [Journal Article] Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox (2011)
  • Author(s): Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R., Sawamura, T.
  • Journal Title: Proc Jpn Acad Ser B Phys Biol Sci 87(3) Pages: 104-113
  • NAID: 130000669114
  • Peer Reviewed
• [Journal Article] Procyanidins are potent inhibitors of LOX-1 : a new player in the French Paradox (2011)
  • Author(s): Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R., Sawamura, T.
  • Journal Title: Proc Jpn Acad Ser B Phys Biol Sci Volume: 87(3) Pages: 104-113
  • NAID: 130000669114
  • Peer Reviewed
• [Journal Article] LOX-1 mediates vascular lipid retention under hypertensive state (2010)
  • Author(s): Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H., Sawamura, T.
  • Journal Title: J Hypertens 28(6) Pages: 1273-1280
  • Peer Reviewed
• [Journal Article] Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans (2010)
  • Author(s): Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K., Horie, M.
  • Journal Title: Lipids 45(4) Pages: 329-335
  • Peer Reviewed
• [Journal Article] Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts (2010)
  • Author(s): Takaya, T., Wada, H., Morimoto, T., Sunagawa, Y., Kawamura, T., Takanabe-Mori, R., Shimatsu, A., Fujita, Y., Sato, Y., Fujita, M., Kimura, T., Sawamura, T., Hasegawa, K.
  • Journal Title: Circ J 74(4) Pages: 723-729
  • NAID: 10026472482
  • Peer Reviewed
• [Journal Article] LOX index, a novel predictive biochemical marker for coronary heart disease and stroke (2010)
  • Author(s): Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R., Sawamura, T.
  • Journal Title: Clin Chem 56(4) Pages: 550-558
  • Peer Reviewed
• [Journal Article] C-reactive protein uptake by macrophage cell line via class-A scavenger receptor (2010)
  • Author(s): Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R., Sawamura, T.
  • Journal Title: Clin Chem 56(3) Pages: 478-481
  • Peer Reviewed
• [Journal Article] LOX-1 mediates vascular lipid retention under hypertensive state (2010)
  • Author(s): Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H., Sawamura, T.
  • Journal Title: J Hypertens Volume: 28(6) Pages: 1273-1280
  • Peer Reviewed
• [Journal Article] Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans (2010)
  • Author(s): Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K., Horie, M.
  • Journal Title: Lipids Volume: 45(4) Pages: 329-335
  • Peer Reviewed
• [Journal Article] LOX index, a novel predictive biochemical marker for coronary heart disease and stroke (2010)
  • Author(s): Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R., Sawamura, T.
  • Journal Title: Clin Chem Volume: 56(4) Pages: 550-558
  • Peer Reviewed
• [Journal Article] Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts (2010)
  • Author(s): Takaya, T., Wada, H., Morimoto, T., Sunagawa, Y., Kawamura, T., Takanabe-Mori, R., Shimatsu, A., Fujita, Y., Sato, Y., Fujita, M., Kimura, T., Sawamura, T., Hasegawa, K.
  • Journal Title: Circulation Journal 74 Pages: 723-729
  • NAID: 10026472482
  • Peer Reviewed
• [Journal Article] C-reactive protein uptake by macrophage cell line via class-A scavenger receptors (2010)
  • Author(s): Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R., Sawamura, T.
  • Journal Title: Clinical Chemistry 56 Pages: 478-481
  • Peer Reviewed
• [Journal Article] LOX-1-MT1-MMP axis is crucial for RhoA and Racl activation induced by oxidized low-density lipoprotein in endothelial cells (2010)
  • Author(s): Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y., Takeishi, Y.
  • Journal Title: Cardiovascular Research 84 Pages: 127-136
  • Peer Reviewed
• [Journal Article] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells (2009)
  • Author(s): Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y., Takeishi, Y.
  • Journal Title: Cardiovasc Res 84(1) Pages: 127-136
  • Peer Reviewed
• [Journal Article] Lox-1 : the multifunctional receptor underlying cardiovascular dysfunction (2009)
  • Author(s): Ogura, S., Kakino, A., Sato, Y., Fujita, Y., Iwamoto, S., Otsui, K., Yoshimoto, R., Sawamura, T.
  • Journal Title: Circ J 73(11) Pages: 1993-1999
  • NAID: 10025936843
  • Peer Reviewed
• [Journal Article] Oxidized LDL receptor LOX-1 (2009)
  • Author(s): Fujita, Y., Sawamura, T.
  • Journal Title: Nippon Yakurigaku Zasshi 133(5) Pages: 295-296
  • NAID: 10025740803
  • Peer Reviewed
• [Journal Article] Lox-1: the multifunctional receptor underlying cardiovascular dysfunctions (2009)
  • Author(s): Ogura, S., Kakino, A., Sato, Y., Fujita, Y., Iwamoto, S., Otsui, K., Yoshimoto, R., Sawamura, T.
  • Journal Title: Circulation Joumal 73 Pages: 1993-1999
  • NAID: 10025936843
  • Peer Reviewed
• [Journal Article] Oxidized LDL receptor LOX-1 (2009)
  • Author(s): Fujita, Y., Sawamura, T.
  • Journal Title: Nippon Yakurigaku Zasshi 133 Pages: 295-296
  • NAID: 10025740803
  • Peer Reviewed
• [Presentation] プロシアニジンはLOX-1アンタゴニストであり、血管壁への脂質沈着を抑制する (2011)
  • Author(s): 善本亮、西塚太一、藤田佳子、佐藤優子、中野厚史、垣野明美、大嶋俊二、神田智正、沢村達也
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 誌上開催
  • Year and Date: 2011-03-23
• [Presentation] プロシアニジンはLOX-1アンタゴニストであり、血管壁への脂質沈着を抑制する (2011)
  • Author(s): 善本亮、西塚太一、藤田佳子、佐藤優子、中野厚史、垣野明美、大嶋俊二、神田智正、沢村達也
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-03-23
• [Presentation] 酸化LDL測定のための人工標準蛋白作製 (2010)
  • Author(s): 岩元真、藤田佳子、垣野明美、柳田一樹、善本亮、沢村達也
  • Organizer: 第83回日本生化学会大会、第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] プロシアニジンは酸化LDL受容体LOX-1のアンタゴニストであり、ラット血管壁への脂質沈着を抑制する (2010)
  • Author(s): 西塚太一、藤田佳子、佐藤優子、中野厚史、垣野明美、大嶋俊二、神田智正、善本亮、沢村達也
  • Organizer: 第20回日本循環薬理学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-11-11
• [Presentation] C-REACTIVE PROTEIN BINDS TO LOX-1 AND CAUSES VASCULAR DYSFUNCTION VIA COMPLEMENT ACTIVATION (2010)
  • Author(s): 藤田佳子、乙井一典、垣野明美、山口三郎、佐藤優子、善本亮、沢村達也
  • Organizer: International SHR Symposium
  • Place of Presentation: モントリオール
  • Year and Date: 2010-09-25
• [Presentation] LOX-1 is involved in the complement activation by endogenous C-reactive protein and myocardial reperfusion injury (2010)
  • Author(s): 藤田佳子、乙井一典、垣野明美、山口三郎、佐藤優子、善本亮、沢村達也
  • Organizer: 15th World Congress on Heart Disease
  • Place of Presentation: バンクーバー
  • Year and Date: 2010-07-25
• [Presentation] LOX-1 is involved in the complement activation by endogenous C-reactive protein and myocardial reperfusion injury (2010)
  • Author(s): 藤田佳子、乙井一典、垣野明美、山口三郎、佐藤優子、善本亮、沢村達也
  • Organizer: 15th World Cogress on Heart Disease
  • Place of Presentation: バンクーバー
  • Year and Date: 2010-07-25
• [Presentation] The effect of LOX-1 and LOX-1 ligand containing ApoB on the incidence of coronary heart disease and stroke in an 11-year population-based cohort study : The Suita study (2010)
  • Author(s): Okamura, T., Inoue, N., Kokubo, Y., Fujita, Y., Sato, Y., Watanabe, M., Sawamura, T.
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] The effect of LOX-1 and LOX-1 ligands containing ApoB on the incidence of coronary heart disease and stroke in an 11-year population-based cohort study : The Suita study (2010)
  • Author(s): Okamura, T., Inoue, N., Kokubo, Y., Fujita, Y., Sato, Y., Watanabe, M., Sawamura, T.
  • Organizer: 第42回日本動脈硬化学会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-16
• [Presentation] Recognition of endogenous C-reactive protein by LOX-1 abrogates myocardial infarction (2010)
  • Author(s): 藤田佳子、乙井一典、垣野明美、山口三郎、佐藤優子、善本亮、沢村達也
  • Organizer: ISHR (World Congress of the International Society for Heart Research)
  • Place of Presentation: 京都
  • Year and Date: 2010-05-13
• [Presentation] CRPはSR-Aを介してマクロファージに取り込まれる (2010)
  • Author(s): 藤田佳子、垣野明美、佐藤優子、善本亮、沢村達也
  • Organizer: 第83回薬理学会年会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-03-16
• [Presentation] CRPはSR-Aを介してマクロファージに取り込まれる (2010)
  • Author(s): 藤田佳子、垣野明美、佐藤優子、善本亮、沢村達也
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪(大阪国際会議場)
  • Year and Date: 2010-03-16
• [Presentation] HSP90は細胞膜受容体を介して血管新生を促進する (2009)
  • Author(s): 佐藤優子、藤田佳子、垣野明美、小倉紗世子、岩元真、善本亮、沢村達也
  • Organizer: 第19回日本循環薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-27
• [Presentation] HSP90は細胞膜受容体を介して血管新生を促進する (2009)
  • Author(s): 佐藤優子、藤田佳子、垣野明美、小倉彩世子、岩元真、善本亮、沢村達也
  • Organizer: 第19回日本循環薬理学会
  • Place of Presentation: 京都(京都大学)
  • Year and Date: 2009-11-27
• [Presentation] CRPによる心筋梗塞悪化へのLOX-1の関与 (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、沢村達也
  • Organizer: 日本心血管内分泌代謝学会
  • Place of Presentation: 大宮
  • Year and Date: 2009-10-24
• [Presentation] CRPによる心筋梗塞悪化へのLOX-1の関与 (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、沢村達也
  • Organizer: 第13回日本心血管内分泌代謝学会
  • Place of Presentation: 埼玉(大宮ソニックシティ)
  • Year and Date: 2009-10-24
• [Presentation] CRPはLOX-1依存性に補体系を活性化し、心筋梗塞を悪化させる (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、沢村達也
  • Organizer: 第45回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 東京(東京ステーションコンフアレンス)
  • Year and Date: 2009-09-05
• [Presentation] CRPはLOX-1依存性に補体系を活性化し、心筋梗塞を悪化させる (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、沢村達也
  • Organizer: 高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-04
• [Presentation] 酸化LDL受容体LOX-1はCRPと協調して血管機能変化・心筋梗塞巣拡大を引き起こす (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、小倉紗世子、岩元真、沢村達也
  • Organizer: 第7回メタボリックシンドローム研究会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-18
• [Presentation] 酸化LDL受容体LOX-1はCRPと協調して血管機能変化・心筋梗塞巣拡大を引き起こす (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、小倉彩世子、岩元真、沢村達也
  • Organizer: 第7回メタボリックシンドローム研究会
  • Place of Presentation: 京都(ホテルグランヴィア京都)
  • Year and Date: 2009-07-18
• [Presentation] LOX-1 BINDS TO C-REACTIVE PROTEIN AND MEDIATES ITS EFFECTS ON CARDIOVASCULAR SYSTEM (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、西道教尚、山口三郎、松田治男、沢村達也
  • Organizer: 国際動脈硬化学会
  • Place of Presentation: ボストン
  • Year and Date: 2009-06-17
• [Presentation] LOX-1 BINDS TO C-REACTIVE PROTEIN AND MEDIATES ITS EFFECTS ON CARDIOVASCULAR SYSTEM (2009)
  • Author(s): 藤田佳子、垣野明美、乙井一典、山口三郎、西道教尚、松田治男、沢村達也
  • Organizer: XV International Symposium on Atherosclerosis
  • Place of Presentation: Boston, MA, USA (John B.Hynes Veterans Memorial Convention Center)
  • Year and Date: 2009-06-16
• [Remarks] ホームページ等なし