Regulation of inflammatory cytokine processing by a phospholipid-metabolizing enzyme.

• Project/Area Number: 21790262
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Akita University
• Principal Investigator: SASAKI Junko Akita University, 大学院・医学系研究科, 講師 (30333371)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: リン脂質 / 細胞・組織 / 遺伝子改変動物 / 脂質

Research Abstract

L-PIPase(leucine-rich phosphoinositide phosphatase)is a phospholipid-metabolizing enzyme. We found a protein X as a binding partner of L-PIPase. We investigated the participation of L-PIPase in inflammatory cytokine processing through the interaction of L-PIPase with protein X.

Research Products

• [Journal Article] The Ras-PI3K signaling pathway is involved in c1athrin-independent endocytosis and the internalization of influenza viruses. (2011)
  • Author(s): Fujioka, Y., Tsuda, M., Hattori, T., Sasaki, J., Sasaki, T., Miyazaki, T., Ohba, Y.
  • Journal Title: PLoS One 6
  • Peer Reviewed
• [Journal Article] The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. (2011)
  • Author(s): Fujioka, Y.
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] The PI (3,4) P2 phosphatase INPP4A is a suppressor of excitotoxic Neuronal Death. (2010)
  • Author(s): Sasaki, J., Kofuji, S., Itoh, R., Momiyama, T., Takayama, K., Murakami, H., Chida, S., Tsuya, Y., Takasuga, S., Eguchi, S., Asanuma, K., Horie, Y., Miura, K., Davis, M., Mitchell, C., Yamazaki, M., Hirai, H., Takenawa, T., Suzuki, A., Sasaki, T.
  • Journal Title: Nature 465 Pages: 497-501
  • Peer Reviewed
• [Journal Article] Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4, 5-bisphosphate synthesis in the brain. (2010)
  • Author(s): Volpicelli-Daley, L., A., Lucast, L., Gong, L., W., Liu, L., Sasaki, J., Sasaki, T., Abrams, C., S., Kanaho, Y., DeCamilli, P.
  • Journal Title: J.Biol.Chem. 285 Pages: 28708-28714
  • Peer Reviewed
• [Journal Article] The PI(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic Neuronal Death. (2010)
  • Author(s): Sasaki, J.
  • Journal Title: Nature Volume: 465 Pages: 497-501
  • Peer Reviewed
• [Journal Article] Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. (2010)
  • Author(s): Volpicelli-Daley, L.A.
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 28708-28714
  • Peer Reviewed
• [Journal Article] Sex difference in the liver of hepatocyte-specific Pten-deficient mice : A model of nonalcoholic steatohepatitis. (2009)
  • Author(s): Anezaki, Y., Ohshima, S., Ishii.H., Kinoshita, N., Dohmen, T., Kataoka, E., Sato, W., I izuka, M., Goto, T., Sasaki, J., Sasaki, T., Suzuki, A., Ohnishi, H., Horie, Y.
  • Journal Title: Hepatol.Res. 39 Pages: 609-618
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. (2009)
  • Author(s): Ishii, H., Horie, Y., Ohshima, S., Anezaki, Y., Kinoshita, N., Dohmen, T., Kataoka, E., Sato, W., Goto, T., Sasaki, J., Sasaki, T., Watanabe, S., Suzuki, A., Ohnishi, H.
  • Journal Title: J.Hepatol. 50 Pages: 562-571
  • Peer Reviewed
• [Journal Article] Mammalian phosphoinositide kinases and phosphatases. (2009)
  • Author(s): Sasaki, T., Takasuga, S., Sasaki, J., Kofuji, S., Eguchi, S., Yamazaki, M., Suzuki, A.
  • Journal Title: Prog.Lipid Res. 48 Pages: 307-343
• [Journal Article] Mammalian phosphoinositide kinases and phosphatases (2009)
  • Author(s): Sasaki, T.
  • Journal Title: Prog.Lipid Res. 48 Pages: 307-343
  • Peer Reviewed
• [Journal Article] Sex difference in the liver of hepatocyte-specific Pten-deficient mice : Amodel of nonalcoholic steatohepatitis (2009)
  • Author(s): Anezaki, Y.
  • Journal Title: Hepatol.Res. 39 Pages: 609-618
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice (2009)
  • Author(s): Ishii, H.
  • Journal Title: J.Hepatol. 50 Pages: 562-571
  • Peer Reviewed
• [Presentation] The lipid phosphatase INPP4A prevents striatal neurons from excitotoxic death. (2010)
  • Author(s): 佐々木純子
  • Organizer: BMB2010
  • Place of Presentation: ポートピアホテル(兵庫県)
  • Year and Date: 2010-12-08
• [Presentation] The lipid phosphatase INPP4A prevents striatal neurons from excitotoxic death (2010)
  • Author(s): 佐々木純子
  • Organizer: BMB2010
  • Place of Presentation: ポートピアホテル(兵庫県)
  • Year and Date: 2010-12-08
• [Remarks] ホームページ等
  • URL: http://www.med.akita-u.ac.jp/~bisei/
• [Remarks]
  • URL: http://www.med.akita-u.ac.jp/~bisei/
• [Remarks]
  • URL: http://www.med.akita-u.ac.jp/~bisei/