Roles of Dok-7 and MuSK in neuromuscular synaptogenesis
| Project/Area Number |
21790266
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TEZUKA Tohru The University of Tokyo, 医科学研究所, 助教 (50312319)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 神経筋接合部 / シグナル伝達 / チロシンリン酸化 |
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| Research Abstract |
The neuromuscular junction (NMJ) is a synapse between a motor neuron and skeletal muscle. Defects in the formation and function of the NMJ are associated with neuromuscular disorders such as congenital myasthenic syndromes and myasthenia gravis. The muscle-specific receptor tyrosine kinase MuSK and its cytoplasmic activator Dok-7 are essential for the formation of the NMJ. To understand the molecular mechanism underlying Dok-7-mediated activation of MuSK and intracellular signaling evoked by activation of MuSK, we carried out proteomic studies. We identified proteins that bound to MuSK and Dok-7, and those that were phosphorylated upon activation of MuSK in cultured myotubes. Roles of these proteins in the formation and function of the NMJ are under investigation.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.2010
Author(s)
Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T.
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Journal Title
Mol Brain. 3
Pages: 37-37
Related Report
Peer Reviewed
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[Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.2009
Author(s)
Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T.
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Journal Title
EMBO J. 28(23)
Pages: 3717-3729
Related Report
Peer Reviewed
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