CommonMechanismforCancerProgressionandStratificationofEpithelia

• Project/Area Number: 21790267
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Kyoto University (2011-2012); Tokyo Medical and Dental University (2009-2010)
• Principal Investigator: MATSUI Takeshi 京都大学, 物質-細胞統合システム拠点, 特定拠点助教 (10452442)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 癌 / 細胞・組織 / 発生・分化 / プロテアーゼ / 皮膚 / 表皮 / 上皮 / 欠損マウス / SASPase / Dermokine / 上皮細胞 / dermokine / 早期癌 / 分泌蛋白質 / ノックアウトマウス / アイソフォーム / 重層扁平上皮組織

Research Abstract

Skin-specific secreted peptide, dermokine was expressed in colorectal and pancreatic cancer at the early-stageof carcinogenesis. Serum dermokine was potential biomarker in these cancers. In addition, activity of skin-specific protease, SASPase plays a key role in stratum corneum hydration through profilaggrin processing. SASPase was also expressed at the early-stage of carcinogenesis. These results suggested the potential link between cancer progression and stratification of epithelia.

Research Products

• [Journal Article] Dermokine Expression in Intraductal Papillary-Mucinous Neoplasm and Invasive Pancreatic Carcinoma (2012)
  • Author(s): Watanabe K, Oochiai T, Kikuchi S, Kumano T, Matsui T, Morimoto K, Yasukawa S, Nakamori S, Sasako M, Yanagisawa A, Otsuji E
  • Journal Title: Anticancer Res Volume: 32 Pages: 4405-4412
  • Peer Reviewed
• [Journal Article] Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma (2012)
  • Author(s): Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J
  • Journal Title: Clin Cancer Res Volume: 18 Issue: 13 Pages: 3541-51
  • DOI: 10.1158/1078-0432.ccr-11-1007
  • Peer Reviewed
• [Journal Article] Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin (2012)
  • Author(s): Sandilands A,Brown SJ, Goh CS, Pohler E, Wilson NJ, Campbell LE, Miyamoto K, Kubo A, Irvine AD, Thawer-Esmail F, Munro CS, McLean WH, Kudoh J, Amagai M, Matsui T
  • Journal Title: J. Invest. Dermatol Volume: 132 Issue: 5 Pages: 1507-10
  • DOI: 10.1038/jid.2011.479
  • Peer Reviewed
• [Journal Article] SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation (2012)
  • Author(s): Ono H, Imoto I, Kozaki K, Tsuda H, Matsui T, Kurasawa Y, Muramatsu T, Sugihara K, Inazawa J
  • Journal Title: Oncogene Volume: 31 Issue: 47 Pages: 4923-4934
  • DOI: 10.1038/onc.2011.646
  • Peer Reviewed
• [Journal Article] Dermokine expression in intraductal papillary-mucinous neoplasm and invasive pancreatic carcinoma. (2012)
  • Author(s): Watanabe K, Oochiai T, Kikuchi S, Kumano T, Matsui T, Morimoto K, Yasukawa S, Nakamori S, Sasako M, Yanagisawa A, Otsuji E
  • Journal Title: Anticancer Res Volume: 32 Pages: 4405-4412
  • Peer Reviewed
• [Journal Article] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M
  • Journal Title: EMBO Mol. Med Volume: 3 Issue: 6 Pages: 320-333
  • DOI: 10.1002/emmm.201100140
  • Peer Reviewed
• [Journal Article] YAP is a candidate oncogene for esophageal squamous cell carcinoma (2011)
  • Author(s): Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T, Inazawa J
  • Journal Title: Carcinogenesis Volume: 32 Issue: 3 Pages: 389-398
  • DOI: 10.1093/carcin/bgq254
  • Peer Reviewed
• [Journal Article] 脊椎動物陸上進出の謎と美容-表皮顆粒層に特異的に発現するレトロウイルス様アスパラギン酸プロテアーゼSASPaseの研究を通して- (2011)
  • Author(s): 松井毅
  • Journal Title: 日本美容皮膚科学会誌 Volume: 21 Pages: 277-287
• [Journal Article] Dermokine as a novel biomarker for early-stage colorectal cancer (2010)
  • Author(s): Tagi T, Matsui T, Kikuchi S, Hoshi S, Ochiai T, Kokuba Y, Kinoshita-Ida Y, Kisumi-Hayashi F, Morimoto K, Imai T, Imoto I, Inazawa J, Otsuji E
  • Journal Title: J. Gastroenterol Volume: 45 Issue: 12 Pages: 1201-11
  • DOI: 10.1007/s00535-010-0279-4
  • NAID: 10027700010
  • Peer Reviewed
• [Journal Article] Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous-cell carcinoma (2010)
  • Author(s): Haruki S, Imoto I, Kozaki K, Matsui T, Kawachi H, Komatsu S, Muramatsu T, Shimada Y, Kawano T, Inazawa J
  • Journal Title: Carcinogenesis Volume: 31 Issue: 6 Pages: 1027-36
  • DOI: 10.1093/carcin/bgq053
  • Peer Reviewed
• [Journal Article] Dermokine as a novel biomarker forearly-stage colorectal cancer (2010)
  • Author(s): Tagi T, Matsui T, Kikuchi S, Hoshi S, Ochiai T, Kokuba Y, Kinoshita-Ida Y, Kisumi-Hayashi F, Morimoto K, Imai T, Imoto I, Inazawa J, Otsuji E (Equal contribution)
  • Journal Title: Journal of Gastroenterology Volume: 45 Pages: 1201-1211
  • NAID: 10027700010
  • Peer Reviewed
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and Evolution (2013)
  • Author(s): Matsui T
  • Organizer: RSC-iCeMS Joint International Symposium Cell-Material Integration and Biomaterial Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2013-03-18
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and Evolution (2013)
  • Author(s): 松井 毅
  • Organizer: RSC-iCeMS Joint International Symposium Cell-Material Integrationand Biomaterial Sciences
  • Place of Presentation: 京都大学医学部芝蘭会館（京都府）
  • Invited
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and Evolution. RSC-iCeMS Joint IaMammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and (2012)
  • Author(s): Matsui T
  • Organizer: The 35th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-12-13
• [Presentation] Endogenous Retroviral-like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Organizer: The Montagna Symposium on the Biology of the Skin
  • Place of Presentation: Oregon, USA
  • Year and Date: 2012-10-12
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Organizer: Fujihara Seminar 2012: A new horizon of retroposon research
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-03
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Organizer: Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
  • Place of Presentation: Kobe
  • Year and Date: 2012-05-29
• [Presentation] Endogenous Retroviral-like Aspartic Protease, SASPase as a key modulator of skin moisturization (2012)
  • Author(s): Matsui T
  • Organizer: The 8th Okazaki Biology Conference: Speciation and Adaptation II - Environment and Epigenetics -
  • Place of Presentation: Okazaki
  • Year and Date: 2012-03-23
• [Presentation] Endogenous Retroviral-like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization and Evolution (2012)
  • Author(s): Matsui T
  • Organizer: 6th Annual Symposium on Nanobiotechnology, Cell-Material Integration and Biomaterial Sciences
  • Place of Presentation: Kyoto
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and Evolution (2012)
  • Author(s): 松井 毅
  • Organizer: The 35th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Fukuoka International Congress Center, Marine Messe Fukuoka（福岡県）
  • Invited
• [Presentation] Retroviral-like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization and Evolution (2012)
  • Author(s): 松井 毅
  • Organizer: 6th Annual Symposium on Nanobiotechnology, Kyoto Cell-Material Integration
  • Place of Presentation: 京都大学医学部芝蘭会館（京都府）
• [Presentation] Endogenous Retroviral-like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization (2012)
  • Author(s): 松井 毅
  • Organizer: The Montagna Symposium on the Biology of the Skin
  • Place of Presentation: Salishan Resort (アメリカ）
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization (2012)
  • Author(s): 松井 毅
  • Organizer: Fujihara Seminar 2012A new horizon of retroposon research
  • Place of Presentation: 京都大学医学部芝蘭会館（京都府）
  • Invited
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization (2012)
  • Author(s): 松井 毅
  • Organizer: Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
  • Place of Presentation: Kobe International Conference Center(兵庫県）
  • Invited
• [Presentation] Evolutionally integrated retroviral-like aspartic protease, SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T
  • Organizer: The 34th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2011-12-13
• [Presentation] Evolutionally integrated retroviral-like aspartic protease, SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): 松井毅、宮本憲、久保亮治、川崎洋、海老原全、畑和也、市野瀬志津子、井本逸勢、稲澤譲治、工藤純、天谷雅行
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜・神奈川
  • Year and Date: 2011-12-13
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): 松井毅、宮本憲、久保亮治、川崎洋、海老原全、畑和也、市野瀬志津子、井本逸勢、稲澤譲治、工藤純、天谷雅行
  • Organizer: 日本研究皮膚科学会第36回年次学術大会
  • Place of Presentation: 京都国際会館・京都
  • Year and Date: 2011-12-10
• [Presentation] 表皮の顆粒層特異的に発現するプロテアーゼSASPaseによる、角質層水分量の制御機構 (2011)
  • Author(s): Matsui T
  • Organizer: The 61st Annual Meeting of Japanese Society of Allergology
  • Place of Presentation: Tokyo
  • Year and Date: 2011-11-11
• [Presentation] 表皮の顆粒層特異的に発現するプロテアーゼSASPaseによる、角質層水分量の制御機構 (2011)
  • Author(s): 松井毅
  • Organizer: 第61回日本アレルギー学会秋期学術大会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール・東京(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] 皮膚表皮顆粒層特異的なレトロウイルス型アスパラギン酸プロテアーゼSASPaseは、ProfilaggrinからFilaggrinへの分解を制御し、角質層の水分量を調節する (2011)
  • Author(s): Matsui T
  • Organizer: The 84th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Kyoto
  • Year and Date: 2011-09-22
• [Presentation] 皮膚表皮顆粒層特異的なレトロウイルス型アスパラギン酸プロテアーゼSASPaseは、ProfilaggrinからFIlaggrinへの分解を制御し、角質層の水分量を調節する (2011)
  • Author(s): 松井毅、宮本憲、久保亮治、川崎洋、海老原全、畑和也、市野瀬志津子、井本逸勢、稲澤譲治、工藤純、天谷雅行
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館・京都
  • Year and Date: 2011-09-22
• [Presentation] 脊椎動物陸上進出の謎と皮膚の美容 (2011)
  • Author(s): Matsui T
  • Organizer: The 29th Annual Meeting of the Japanese Society of Aesthetic Dermatology
  • Place of Presentation: Yamaguchi
  • Year and Date: 2011-09-10
• [Presentation] 脊椎動物陸上進出の謎と皮膚の美容 (2011)
  • Author(s): 松井毅
  • Organizer: 第29回日本美容皮膚科学会総会・学術大会
  • Place of Presentation: 海峡メッセ下関・山口(招待講演)
  • Year and Date: 2011-09-10
• [Presentation] 陸上脊椎動物において獲得された皮膚表皮顆粒層特異的なレトロウイルス型プロテアーゼSASPaseは、角質層の水分量を調節する (2011)
  • Author(s): Matsui T
  • Organizer: Annual Meeting for the Society of Evolutionary Studies
  • Place of Presentation: Kyoto
  • Year and Date: 2011-07-30
• [Presentation] 陸上脊椎動物において獲得された皮膚表皮顆粒層特異的なレトロウイルス型プロテアーゼSASPaseは、角質層の水分量を調節する (2011)
  • Author(s): 松井毅、宮本憲、久保亮治、川崎洋、海老原全、畑和也、市野瀬志津子、井本逸勢、稲澤譲治、工藤純、天谷雅行
  • Organizer: 日本進化学会第13回大会
  • Place of Presentation: 京都大学
  • Year and Date: 2011-07-30
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M
  • Organizer: Heidelberg-Kyoto Joint Symposium "Crossing Boundaries : Stem Cells, Materials, and Mesoscopic Sciences"
  • Place of Presentation: DFKZ, Heidelberg University, Germany
  • Year and Date: 2011-07-21
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M
  • Organizer: Epithelial Differentiation & Keratinization Gordon Research Conference
  • Place of Presentation: Mount Snow Resort, USA
  • Year and Date: 2011-07-05
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing. Heidelberg-Kyoto Joint Symposium (2011)
  • Author(s): Matsui T
  • Organizer: Crossing Boundaries: Stem Cells, Materials, and Mesoscopic Sciences
  • Place of Presentation: Heidelberg, Germany
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T
  • Organizer: Epithelial Differentiation & Keratinization Gordon Research Conference
  • Place of Presentation: USA
• [Presentation] Analysis and clinical application of dermokines, stratified epithelia-specific secreted proteins (2009)
  • Author(s): Matsui T
  • Organizer: Gordon research Conference-Epithelial Differentiation & Keratinization
  • Place of Presentation: Les Diabretes, Switzerland
  • Year and Date: 2009-06-24
• [Presentation] Analysis and clinical application of dermokines, stratified epithelia-specific secreted proteins (2009)
  • Author(s): 松井毅
  • Organizer: Gordon research Conference-Epithelial Differentiation & Keratinization
  • Place of Presentation: スイス。デレアブレ
  • Year and Date: 2009-06-24
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing
  • Author(s): Matsui T
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Kyoto
• [Book] Endogenous Retroviral-Like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Publisher: Treatment of Dry Skin Syndrome -The Art and Science of Moisturizers- Edited by Loden and Maibach, Springer, Part 2
• [Book] Treatment of Dry Skin Syndrome -The Art and Science of Moisturizers- (2012)
  • Author(s): T Matsui
  • Total Pages: 14
  • Publisher: Springer
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