Differentiation of steroidogenic cells from stem cells.
Project/Area Number |
21790269
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
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Research Institution | University of Fukui |
Principal Investigator |
YAZAWA Takashi University of Fukui, 医学部, 助教 (00334813)
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Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 再生医学 / 幹細胞 / SF-1 / ステロイドホルモン / 間葉系幹細胞 / PGC-1α / 顆粒膜細胞 |
Research Abstract |
In this study, I developed a method for differentiation of ES cells into steroidogenic cells by a tetracycline regulated gene expression system for SF-1 using ROSA-TET system. I also revealed that PGC-1α is important for the progesterone production in ovarian granulosa cells.
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Report
(3 results)
Research Products
(57 results)
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[Journal Article] Stem cell differentiation into steroidogenic cell lineages by NR5A family.2011
Author(s)
Miyamoto, K., Yazawa, T., Mizutni, T., Imamichi, Y., Kawabe, S., Ju, Y., Umezawa, A.
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Journal Title
Mol.Cell.Endocrinol. 336
Pages: 123-126
Related Report
Peer Reviewed
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[Journal Article] Differentiation of mesenchymal stem cells and embryonic stem cells into steroidogenic cells using steroidogenic factor-1 and liver receptor homolog-1.2011
Author(s)
Yazawa, T., Kawabe, S., Inaoka, Y., Okada, R., Mizutani, T., Imamichi, Y., Ju, Y., Yamazaki, Y., Usami, Y., Kuribayashi, M., Umezawa, A., Miyamoto, K.
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Journal Title
Mol.Cell.Endocrinol. 336
Pages: 127-132
Related Report
Peer Reviewed
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[Journal Article] High temperature causes masculinization of genetically female medaka by elevation of cortisol level.2011
Author(s)
Hayashi, Y., Kobira, H., Yamaguchi, T., Shiraishi, E., Yazawa, T., Hirai, T., Kamei, Y., Kitano, T.
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Journal Title
Mol.Reprod.Dev. 77(8)
Pages: 679-686
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel distal control region upstream of the human steroidogenic acute regulatory protein (StAR) gene that participates in SF-1-dependent chromatin architecture.2010
Author(s)
Mizutani, T., Yazawa, T., Ju, Y., Imamichi, Y., Uesaka, M., Inaoka, Y., Matsuura, K., Kamiki, Y., Oki, M., Umezawa, A., Miyamoto, K.
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Journal Title
J.Biol.Chem. 285(36)
Pages: 28240-28251
Related Report
Peer Reviewed
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[Journal Article] Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha regulates progesterone production in ovarian granulosa cells with steroidogenic factor-1 and liver receptor homolog-1.2010
Author(s)
Yazawa, T., Inaoka, Y., Okada, R., Mizutani, T., Yamazaki, Y., Usami, Y., Kuribayashi, M., Orisaka, M., Umezawa, A., Miyamoto, K.
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Journal Title
Mol.Endocrinol. 24(3)
Pages: 485-496
Related Report
Peer Reviewed
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[Journal Article] Liver Receptor Homolog-1 regulates the transcription of steroidogenic enzymes and induces the differentiation of mesenchymal stem cells into steroidogenic cells.2009
Author(s)
Yazawa, T., Inaoka, Y., Mizutani, T., Kuribayashi, M., Umezawa, A., Miyamoto, K.
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Journal Title
Endocrinology 150(8)
Pages: 3885-3893
Related Report
Peer Reviewed
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[Presentation] ヒトStAR遺伝子の新たな転写調節機構2010
Author(s)
水谷哲也, 矢澤隆志, 具云峰, 今道力敬, 松村健大, 河邉真也, 松浦かおる, 上木康衣, 梅澤明弘, 宮本薫
Organizer
日本生化学会北陸支部第28回大会
Place of Presentation
福井
Year and Date
2010-05-29
Related Report
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[Presentation] PGC-1αはSF-1とLRH-1のコアクチベーターとしてプロジェステロン産生を促進する2010
Author(s)
矢澤隆志, 稲岡斉彦, 岡田令子, 河邉真也, 水谷哲也, 今道力敬, 山崎由希子, 宇佐美陽子, 栗林真悠, 梅澤明弘, 宮本薫
Organizer
第83回日本生化学会大会・第33回日本分子生物学会年会 BMB2010.
Place of Presentation
神戸
Related Report
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[Presentation] クロマチン構造変換を介したStARの新たな転写調節メカニズム2010
Author(s)
水谷哲也, 具云峰, 今道力敬, 松村健大, 矢澤隆志, 河邉真也, 菅野真史, 松浦かおる, 上木康衣, 梅澤明弘, 尾崎司, 南野直人, 宮本薫
Organizer
第83回日本生化学会大会・第33回日本分子生物学会年会 BMB2010.
Place of Presentation
神戸
Related Report
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[Presentation] 卵巣・顆粒膜細胞におけるアンドロジェンの作用2010
Author(s)
矢澤隆志, 河邉真也, 稲岡斉彦, 岡田令子, 水谷哲也, 今道力敬, 山崎由希子, 宇佐美陽子, 栗林真悠, 梅澤明弘, 宮本薫
Organizer
日本動物学会第81回大会
Place of Presentation
東京
Related Report
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[Presentation] Regulation of SF-1-mediated transcription of the human steroidogenic acute regulatory protein gene by chromation-loop formation.2010
Author(s)
Mizutani, T., Yazawa, T., Ju, Y., Uesaka, M., Inaoka, Y., Imamichi, Y., Matsuura, K., Kamiki, Y., Umezawa, A., Miyamoto, K.
Organizer
The 92th Annual Meeting & Expo
Place of Presentation
San Diego.
Related Report
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[Presentation] Identification of a novel enhancer region in the human steroidogenic acute regulatory protein (StAR) gene.2010
Author(s)
Mizutani, T., Yazawa, T., Uesaka, M., Inaoka, Y., Ju, Y., Okada, R., Matsuura, K., Kamiki, Y., Umezawa, A., Miyamoto, K.
Organizer
14th International Congress of Endocrinology.
Place of Presentation
Kyoto.
Related Report
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