Studies on the roles of Periplakin in liver
Project/Area Number |
21790272
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
ITO Shinji 京都大学, 医学研究科, 助教 (50362512)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 肝臓 / 遺伝子発現 / 恒常性維持 / Periplakin / 胆汁鬱滞 / FXR / 炎症 / 胆汁酸 / 遺伝子発現制御 |
Research Abstract |
Periplakin is one of the plakin family of cytokinker proteins whose physiological roles in vivo is not fully elucidated. We have revealed that periplakin massively accumulates in hepatocytes following cholestatic injury. In addition, periplakin-null mice exhibited difference in the expression of genes related to hepatic homeostasis. Therefore, periplakin is likely involved in keeping hepatic homeostasis under cholestatic situations in liver.
|
Report
(4 results)
Research Products
(4 results)
-
[Journal Article] Relevant use of Klotho in FGF19subfamily signaling system in vivo2010
Author(s)
Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji ItoKen-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito
-
Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 107(4)
Issue: 4
Pages: 1666-1671
DOI
Related Report
Peer Reviewed
-
[Journal Article] Relevant use of Klotho in FGF19 subfamily signaling system in vivo2010
Author(s)
Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito, Yoko Nabeshima, Tsutomu Tomita, Shinji Odori, Kiminori Hosoda, Kazuwa Nakao, Akihiro Imura, Yo-ichi Nabeshima
-
Journal Title
Proceedings of the National Academy of Science U.S.A. 107(4)
Pages: 1666-1671
Related Report
Peer Reviewed
-
-