| Project/Area Number |
21790273
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
AOKI Kazuhiro 京都大学, 大学院・生命科学研究科, 講師 (80511427)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | FRET / イメージング / シグナル伝達 / システム生物学 / 癌 / ERK / シミュレーション / リン酸化 / パラメーター |
|---|
| Research Abstract |
ERK MAP kinase is essential for cell proliferation, differentiation and tumorigenetsis. We analyzed molecular mechanisms of ERK phosphorylation by using imaging and computer simulation. Approximately 30 kinetic parameters were measured by experiments. Based on these empirical parameters, we built a simulation model, and found that ERK was processively, but not distributively, phosphorylated by MEK.
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