Mechanism of secreting soluble insulin receptor in diabetes

• Project/Area Number: 21790279
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: The University of Tokushima
• Principal Investigator: NAGAYA Hisao The University of Tokushima, 疾患酵素学研究センター, 助教 (60464343)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 生体分子医学 / インスリンシグナル伝達 / インスリン受容体 / ELISA / MMP

Research Abstract

Insulin is one of the key proteins in diabetes. Insulin receptor is also important in diabetes. We found that soluble insulin receptor in serum is increased in diabetes. In this study, we reconstructed that insulin receptor is released using human cultured cell line and human insulin receptor overexpression cell line. This system will be contributed the uncovering diabetes mechanism.

Research Products

• [Journal Article] 小胞体内分泌タンパク質のダイナミクスの制御機構 (2009)
  • Author(s): 長屋寿雄, 田村拓
  • Journal Title: 生化学(日本生化学会) Vol.81, Issue 7 Pages: 605-609
• [Journal Article] Regulated motion of proteins in the endoplasmic reticulum (2009)
  • Author(s): Nagaya H., Tamura T.
  • Journal Title: Seikagaku 81(7) Pages: 605-609
  • NAID: 10025188391
  • Peer Reviewed
• [Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes. (2010)
  • Author(s): Yuasa Tomoyuki, Nagaya Hisao, Hashida Seiichi, Asako Umehara, Yokota Ichiro, Obata Toshiyuki, Ebina Yousuke
  • Organizer: XI INTERNATIONAL SYMPOSIUM ON INSULIN RECEPTORS AND INSULIN ACTION
  • Place of Presentation: Naplaes
• [Presentation] 可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる (2009)
  • Author(s): 湯浅智之, 他
  • Organizer: 第7回1型糖尿病研究会
  • Place of Presentation: 日光市
  • Year and Date: 2009-11-07
• [Presentation] Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker (2009)
  • Author(s): Yuasa T. et., al.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-01
• [Presentation] Soluble insulin receptor ectodomain level was elevated in the plasma of cancer patients (2009)
  • Author(s): Yuasa T. et., al.
  • Organizer: 第29回日本分子腫瘍マーカー研究会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-09-30
• [Presentation] 可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる (2009)
  • Author(s): 湯浅智之, 小畑利之, 横田一郎, 岡本英治, 長屋寿雄, 橋田誠一, 前川聡, 柏木厚典, 松本満, 松本俊夫, 岸和弘, 蛯名洋介
  • Organizer: 1型糖尿病研究会, 第7回1型糖尿病研究会
  • Place of Presentation: 日光
• [Presentation] Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker, The Japanese Cancer Association (2009)
  • Author(s): Yuasa Tomoyuki, Yano Seiji, Nishioka Yasuhiko, Kubo Yoshiaki, Takahashi Masayuki, Nakatsuji Hiroyoshi, Nagaya Hisao, Kanayama Hiro-omi, Arase Seiji, Sone Saburo, Ebina Yousuke
  • Organizer: 第68回日本癌学会学術総会記事, pp.450-450
  • Place of Presentation: Yokohama
• [Presentation] 可溶化インスリン受容体細胞外ドメイン(sIR)は癌患者血清中で増加している (2009)
  • Author(s): 湯浅智之, 小畑利之, 矢野聖二, 岡本英治, 西岡安彦, 久保宜明, 高橋正幸, 中逵弘能, 長屋寿雄, 金山博臣, 荒瀬誠治, 曽根三郎, 蛯名洋介
  • Organizer: 第29回日本分子腫瘍マーカー研究会事務局, 第29 回日本分子腫瘍マーカー研究会プログラム, pp.70-71
  • Place of Presentation: 横浜
• [Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes. (2009)
  • Author(s): Yuasa Tomoyuki, Obata Toshiyuki, Yokota Ichiro, Okamoto Eiji, Kanezaki Yoshiko, Maegawa Hiroshi, Hirota Fumiko, Kishi Kazuhiro, Hashida Seiichi, Nagaya Hisao, Yuko Ogura, Kazuhiko Masuda, Matsumoto Mitsuru, Matsumoto Toshio, Kashiwagi Atsunori, Ebina Yousuke
  • Organizer: International Symposium on Diabetes -Kickoff of Hannover-Tokushima Research Communiation