Elucidation of mechanisms of generating non-cording RNA involved in tumorigenesis and virus proliferation.
| Project/Area Number |
21790280
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kochi University |
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Principal Investigator |
SAKAMOTO Shuji 高知大学, 教育研究部・医療学系, 助教 (80397546)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | microRNA / NF90-NF45 / 肝細胞がん / プロモーター解析 / トランスジェニックマウス / 筋組織 / ミトコンドリア空胞変性 / PGC-1 / がん / 筋形成 / ミトコンドリア / 空胞変性 / 翻訳 / 核内ミトコンドリア因子 / 核酸 / 癌 / 転写 / マイクロRNA |
|---|
| Research Abstract |
1. We have proposed a novel tumorigenic model in which NF90-NF45 complex raised by E2F1 and 2 transactivators impairs the generation of miR-7 which is known to be an anti-oncomiR, resulting in a promotion of tumorigenesis in hepatocellular carcinoma.
2. We found that an overexpression of NF90 causes muscular atrophy accompanied with mitochondrial disruption via NF90-induced translational repression of nuclear-encoded mitochondria-related proteins such as PGC-1.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] A Novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnomalities induced by gold-thioglucose and a high-fat diet2011
Author(s)
Ogasawara M, Hirose A, Ono M, Aritake K, Nozaki Y, Takahashi M, Okamoto N, Sakamoto S, Iwasaki S, Asanuma T, Taniguchi T, Ueda Y, Onishi S, Saibara T, Oben JA
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Journal Title
Liver International
Volume: 31(4)
Pages: 542-51
Related Report
Peer Reviewed
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[Presentation] A novel regulatory mechanism of cellular energy balance by Nuclear Factor 90(NF90)2011
Author(s)
Shuji Sakamoto, Takuma Higuchi, Yoshihiko Kakinuma, Shoko Kai, Eunsup Chi, Hiroshi Todaka, Keiko Morisawa, Takako Ujihara, Ken-ichi Yagyu, Atsuki Fukushima, Masayuki Tsuda, Taketoshi Taniguchi
Organizer
第34回日本分子生物学会
Place of Presentation
横浜
Related Report
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[Presentation] Nuclear Factor 45(NF45)による細胞増殖促進作用に関与するNF45複合体の同定2011
Author(s)
戸高寛,樋口琢磨,森澤啓子,小野正文,玉置信行,波多野悦郎,氏原隆子,池恩秀,津田雅之,坂本修士,谷口武利
Organizer
第34回日本分子生物学会
Place of Presentation
横浜
Related Report
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[Presentation] 肝細胞癌のおけるNuclear Factor 90(NF90)の発現増加機構の解明2011
Author(s)
樋口琢磨,戸高寛,森澤啓子,小野正文,西原利治,玉置信行,波多野悦郎,竹崎由佳,花崎和弘,津田雅之,坂本修士,谷口武利
Organizer
第34回日本分子生物学会
Place of Presentation
横浜
Related Report
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[Presentation] 遺伝的背景を維持したLewisラットおよびBrown Norwayラット骨髄由来の樹状細胞株の樹立2011
Author(s)
森澤啓子,小味秀行,苫谷文子,近藤基樹,都留忍,戸高寛,樋口琢磨,尾畑恩秀,坂本修士,津田雅之,村上雅尚,大畑雅典,谷口武利
Organizer
第34回日本分子生物学会
Place of Presentation
横浜
Related Report
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[Presentation] Molecular Mechanisms of Muscular Abnormality in Transgenic Mice Overexpressing NF90, a dsRNA binding protein2011
Author(s)
Shuji Sakamoto, Takuma Higuchi, Yoshihiko Kakinuma, Shoko Kai, Hiroshi Todaka, Ken-ichi Yagyu, Eunsup Obata, Keiko Morisawa, Atsuki Fukushima, Masayuki Tsuda, Taketoshi Taniguchi
Organizer
RNA 2011
Place of Presentation
Kyoto
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[Presentation] 肝細胞癌において発現上昇しているNF90遺伝子のプロモーター解析2010
Author(s)
樋口琢磨,坂本修士,氏原隆子,矢生健一,竹崎由佳,上村直,花崎和弘,小野正文,西原利治,玉置信行,波多野悦郎,森澤啓子,戸高寛,甲斐翔子,津田雅之,谷口武利
Organizer
Biochemistry and Molecular Biology 2010
Place of Presentation
神戸
Related Report
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[Presentation] Lewis rat骨髄由来のIL-27発現型dendritic-like cell(DLC)の樹立とその応用2010
Author(s)
樋口琢磨,坂本修士,氏原隆子,矢生健一,竹崎由佳,上村直,花崎和弘,小野正文,西原利治,玉置信行,波多野悦郎,森澤啓子,戸高寛,甲斐翔子,津田雅之,谷口武利
Organizer
第75回日本インターフェロン・サイトカイン学会学術集会
Place of Presentation
北九州
Related Report
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