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Characterization of a novel centrosome-localized protein

Research Project

Project/Area Number 21790287
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionKumamoto University

Principal Investigator

UMEDA Kazuaki  Kumamoto University, 大学院・生命科学研究部, 講師 (80444876)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsFCHO2 / エンドサイトーシス / 中心体 / ガンマ・チュブリン
Research Abstract

We have previously identified the endocytic protein SGIP1α. This molecule through its MP domain binds to phospholipids and deforms the plasma membrane and liposomes into narrow tubes. We have found SGIP1α-related proteins FCHO1 and FCHO2, which have EFC/F-BAR domains substitute for MP domain. We examined the function of FCHO2, including tissue distribution, cellular localization and biochemical properties. Our results indicate that FCHO2 is involved in clathrin-dependent endocytosis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Book (2 results)

  • [Journal Article] Characterization of the EFC/F-BAR domain protein, FCHO22011

    • Author(s)
      上江洲章吉、梅田一彰、辻田和也、末次志郎、竹縄忠臣、中西宏之
    • Journal Title

      Genes to Cells in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier functrion.2010

    • Author(s)
      Sachiko Tsukita
    • Journal Title

      Annals of the New York Academy of Sciences 107

      Pages: 8011-8016

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ZO-1and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function2009

    • Author(s)
      月田早智子、勝野達也、山崎裕自、梅田一彰、田村淳、月田承一郎
    • Journal Title

      Annals of the New York Academy of Sciences 107巻

      Pages: 8011-8016

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] リン脂質結合タンパク質FCHO2 によるインテグリンのエンドサイトーシス制御、文部科学省科学研究費補助金特定領域研究「生体膜トランスポートソームの分子構築と生理機能」2009

    • Author(s)
      梅田一彰、上江洲章吉、菊池直也、中西宏之
    • Organizer
      平成21年度第1回班会議
    • Place of Presentation
      阿蘇リゾートグランヴィリオホテル(熊本県)
    • Related Report
      2010 Final Research Report
  • [Presentation] リン脂質結合タンパク質FCH02によるインテグリンのエンドサイトーシス制御2009

    • Author(s)
      梅田一彰
    • Organizer
      文部科学省科学研究費補助金特定領域研究「生体膜トランスポートソームの分子構築と生理機能」平成21年度第1回班会議
    • Place of Presentation
      阿蘇リゾートグランヴィリオホテル(熊本県)
    • Related Report
      2009 Annual Research Report
  • [Book] トランスポートソームの世界-膜輸送研究の源流から未来へ2011

    • Author(s)
      金井好克, 他
    • Publisher
      京都廣川出版
    • Related Report
      2010 Final Research Report
  • [Book] トランスポートソームの世界-膜輸送研究の源流から未来へ-2011

    • Author(s)
      金井好克
    • Publisher
      京都廣川書店
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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