Molecular mechanisms of opsin transport through cilium in photoreceptor cells
| Project/Area Number |
21790295
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka Bioscience Institute |
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Principal Investigator |
OMORI Yoshihiro Osaka Bioscience Institute, 発生生物学部門, 研究副部長 (90469651)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 網膜 / 神経細胞 / 繊毛 / ゼブラフィッシュ / 細胞死 / 視細胞 / 網膜色素変性症 / 疾患モデルマウス |
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| Research Abstract |
To identify mutations that affect the photoreceptor development and maintenance, we performed early pressure screen using a GFP transgenic line of zebrafish. We showed four mutations which affect ciliary development in photoreceptors. We found that these mutations affect in the ciliogenesis of other sensory neurons including olfactory cells in the nasal pit and hair cells in the inner ear. We also showed that male germ cell-associated kinase, Mak, regulates retinal photoreceptor ciliary length and subcompartmentalization. Our results suggest that Mak is essential for ciliary protein transport, regulation of ciliary length, and is required for the long-term survival of photoreceptors.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina.2011
Author(s)
Omori, Y., Katoh, K., Sato, S., Muranishi, Y., Chaya, T., Onishi, A., Minami, T., Fujikado, T., Furukawa, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.2010
Author(s)
Omori, Y., Chaya, T., Katoh, K., Kajimura, N., Sato, S., Muraoka, K., Ueno, S., Koyasu, T., Kondo, M., Furukawa, T.
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Journal Title
Proc Natl Acad Sci USA. 107
Pages: 22671-22676
Related Report
Peer Reviewed
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[Journal Article] Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization.2010
Author(s)
Kanagawa, M., Omori, Y., Sato, S., Kobayashi, K., Miyagoe-Suzuki, Y., Takeda, S., Endo, T., Furukawa, T., Toda, T.
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Journal Title
J Biol Chem. 285
Pages: 31208-31216
Related Report
Peer Reviewed
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[Journal Article] suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development.2010
Author(s)
Katoh, K., Omori, Y., Onishi, A., Sato, S., Kondo, M., Furukawa, T., Blimp1
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Journal Title
J Neurosci 30
Pages: 6515-6526
Related Report
Peer Reviewed
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[Journal Article] Panky, a novel photoreceptor-specific ankyrin repeat protein, is a transcriptional cofactor that suppresses CRX-regulated photoreceptor genes.2010
Author(s)
Sanuki, R., Omori, Y., Koike, C., Sato, S., Furukawa, T.
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Journal Title
FEBS letter 584
Pages: 753-758
Related Report
Peer Reviewed
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