The timing to establish the circadian rhythms in development
| Project/Area Number |
21790298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Toyohashi University of Technology (2010-2011)
The Institute of Physical and Chemical Research (2009) |
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Principal Investigator |
NUMANO Rika 豊橋技術科学大学, エレクトロニクス先端融合研究所, 特任准教授 (30462716)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 概日リズム / トランスジェニックマウス / 視交叉上核 / 細胞分裂 / 発生 / Tgマウス / Period1遺伝子 / イメージング |
|---|
| Research Abstract |
The neurons in the SCN were developed gradually from fetal to adult by observing cell cycle indicator Fucci Tg mouse. The Dorso Medial in the SCN as pacemaker was developed faster than the Ventro lateral to reset the phase of circadian rhythms. This result was consistent that the circadian rhythms oscillated autonomously since 1week after birth from Per1 : luc Tg mice. The SCN differentiation in pups were compared after pregnant mother mice was kept with mating male or other male. Development in pubs SCN tends to be affected by irregular stimulation to mother mice. It suggests that it is important to keep mother in normal environment for establishing pubs circadian rhythms.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article]2011
Author(s)
Nakane A, Numano R, Takagi Y, Yamaguchi A, Iimura T
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Journal Title
骨形態計測学会雑誌
Volume: 21
Pages: 41-50
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[Journal Article]
Author(s)
Nakane A, Numano R, Sugiyama M, Sato H, Makino Y, Watanabe T, Takagi Y, Yamaguchi A, Iimura T
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Journal Title
J Bone Miner Metab
Volume: (印刷中)
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[Presentation]2010
Author(s)
沼野利佳
Organizer
生命環境科学系生命情報学セミナー(招待講演)
Place of Presentation
東京・東京大学
Year and Date
2010-07-14
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