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Development of a multiphase screening method for genes responsible for age-dependent neurodegenerative disorders

Research Project

Project/Area Number 21790302
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionJuntendo University (2010-2011)
Tohoku University (2009)

Principal Investigator

IMAI Yuzuru  順天堂大学, 大学院・医学研究科, 先任准教授 (30321730)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsパーキンソン病 / LRRK2 / PINK1 / Parkin / 神経変性疾患 / ドーパミン神経 / ショウジョウバエ / ミトコンドリア / ドパミン神経
Research Abstract

PINK1 and LRRK2 are the genes responsible for early-onset and late-onset familial forms of Parkinson’s disease, respectively. I developed a new approach that combines a proteomics analysis and a Drosophila genetic screening to understand the pathogenesis of Parkinson’s disease caused by PINK1 and LRRK2 mutations. Using this approach, I successfully determined molecules that are involved in the PINK1 and LRRK2 pathology, which will contribute to understanding of pathogenesis in these diseases.

Report

(3 results)
  • 2011 Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (49 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (26 results) Book (8 results) Remarks (5 results)

  • [Journal Article] Mitochondrial Dynamics and Mitophagy in Parkinson's disease: Disordered cellular power plant becomes a big deal in a major movement disorder2011

    • Author(s)
      Imai, Y., Lu, B.
    • Journal Title

      Curr Opin Neurobiol

      Volume: 21 Pages: 935-941

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Editorial; Animal models of Parkinson's disease2011

    • Author(s)
      Imai, Y., Venderova, K., Park, DS., Cai, H., Schmidt, E.
    • Journal Title

      Parkinsons Dis

      Volume: Article ID 364328

    • Related Report
      2011 Final Research Report
  • [Journal Article] Dysregulation of microRNA-mediated translational repression is involved in neurodegeneration in a Drosophila model of Parkinson's disease2011

    • Author(s)
      Imai, Y.
    • Journal Title

      Bulletin

      Volume: 75 Pages: 39-56

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Mitochondrial Dynamics and Mitophagy in Parkinson's disease : Disordered cellular power plant becomes a big deal in a major movement disorder2011

    • Author(s)
      Imai Yuzuru
    • Journal Title

      Curr Opin Neurobiol

      Volume: 21 Pages: 935-941

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Editorial ; Animal models of Parkinson's disease2011

    • Author(s)
      Imai Yuzuru
    • Journal Title

      Parkinsons Dis

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010

    • Author(s)
      Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B., Takahashi, R.
    • Journal Title

      PLoS Genet

      Volume: e1001229

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila2010

    • Author(s)
      Kanao, T., Venderova, K., Park, DS., Unterman, T., Lu, B., Imai, Y.
    • Journal Title

      Hum Mol Genet

      Volume: 19 Pages: 3747-3758

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression2010

    • Author(s)
      Gehrke, S., Imai, Y., Sokol, N., Lu, B.
    • Journal Title

      Nature

      Volume: 466 Pages: 637-641

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010

    • Author(s)
      Imai Y., et al
    • Journal Title

      PLoS Genet

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leucine-rich repeat kinase interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease2009

    • Author(s)
      Venderova, K.
    • Journal Title

      Hum Mol Genet. 18

      Pages: 4390-4404

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The HECT-type ubiquitin ligase Huwe1/Mule mediates the stability of PINK12011

    • Author(s)
      澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今居譲
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Translational control and stress response in Parkinson's disease2011

    • Author(s)
      Imai, Y.
    • Organizer
      12th INTERNATIONAL CONGRESS ON AMINO ACIDS, PEPTIDES AND PROTEINS
    • Year and Date
      2011-08-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Translational control and stress response in Parkinson's disease2011

    • Author(s)
      Imai Yuzuru
    • Organizer
      12th INTERNATIONAL CONGRESS ON AMINO ACIDS, PEPTIDES AND PROTEINS
    • Place of Presentation
      北京(招待講演)
    • Year and Date
      2011-08-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] HECT型ユビキチンリガーゼMule/Huwe1によるPINK1安定性の調節2011

    • Author(s)
      澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今居譲
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] The HECT-type ubiquitin ligase HUWE1 mediates the stability of PINK12011

    • Author(s)
      Sawada, T., Kanao, T., Kobayashi, Y., Takahashi, R., Imai, Y.
    • Organizer
      3rd Asian and Oceanian Parkinson's Disease and Movement Disorders Congress
    • Place of Presentation
      Taipei
    • Year and Date
      2011-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] The HECT-type ubiquitin ligase HUWE1 mediates the stability of PINK12011

    • Author(s)
      Sawada T.
    • Organizer
      3^<rd> Asian and Oceanian Parkinson's Disease and Movement Disorders Congress
    • Place of Presentation
      タイペイ、台湾
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pathogenic mechanisms in familial forms of Parkinson's disease revealed by Drosophila models2011

    • Author(s)
      Imai, Y.
    • Organizer
      "MicroRNAs in Neurodegenerative diseases" The 3rd International Symposium of Neurodegeneration Control Research Center
    • Place of Presentation
      Seoul
    • Year and Date
      2011-02-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Pathogenic mechanisms in familial forms of Parkinson's disease revealed by Drosophila models2011

    • Author(s)
      Imai Y.
    • Organizer
      The 3rd International Symposium of Neurodegeneration Control Research Center
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2011-02-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nitric oxide signal modulates FoxO's activity and alters dopaminergic nueron survival and motor activity in Drosophila2010

    • Author(s)
      Kanao, T., Sawada, T., Davies, SA., Moriwaki, Y., Takahashi, R. Imai, Y.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会口演およびポスター
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Identification of Mule as a candidate ubiquitin ligase of PINK12010

    • Author(s)
      Sawada, T., Kanao, T., Kobayashi, Y., Takahashi, R. Imai, Y.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会ポスター
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Nitric oxide signal modulates FoxO's activity and alters dopaminergic nueron survival and motor activity in Drosophila2010

    • Author(s)
      Kanao T.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of Mule as a candidate ubiquitin ligase of PINK12010

    • Author(s)
      Sawada T.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] PINK1のユビキチンリガーゼ候補としてのMule/Huwe1の解析2010

    • Author(s)
      澤田知世, 金尾智子, 小林芳人, 高橋良輔, 今居譲
    • Organizer
      平成22年度Movement Disorder Society Japan学術大会ポスター
    • Place of Presentation
      神戸
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] PINK1のユビキチンリガーゼ候補としてのMule/Huwe1の解析2010

    • Author(s)
      澤田知世
    • Organizer
      平成22年度Movement Disorder Society Japan学術大会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of the PINK1 signaling by a mitochondrial protein PGAM52010

    • Author(s)
      Sawada, T., Kanao, T., Kobayashi, Y., Takahashi, R., Imai, Y.
    • Organizer
      第33回日本神経科学大会口演
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of the PINK1 signaling by a mitochondrial protein PGAM52010

    • Author(s)
      Sawada T.
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] ショウジョウバエパーキンソン病モデルを用いたLRRK2シグナルの解析2010

    • Author(s)
      今居譲
    • Organizer
      グローバルCOEセミナー
    • Place of Presentation
      京都大学
    • Year and Date
      2010-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] ショウジョウバエパーキンソン病モデルを用いたLRRK2シグナルの解析2010

    • Author(s)
      今居譲
    • Organizer
      グローバルCOEセミナー
    • Place of Presentation
      京都大学医学研究科
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010

    • Author(s)
      Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B., Takahashi, R.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会口演およびポスター
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010

    • Author(s)
      Imai Y.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of Pael-R complex components as Parkin substrates2009

    • Author(s)
      澤田知世, 今居譲, 服部信孝, 北山滋雄, 高橋良輔
    • Organizer
      第32回日本分子生物学会年会ポスター
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] LRRK2 phosphorylates FoxO and alters dopaminergic neuron survival in Drosophila2009

    • Author(s)
      Kanao T., Venderova, K., Park, DS., Lu, B., Imai, Y.
    • Organizer
      第32回日本分子生物学会年会口演およびポスター
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] LRRK2 phosphorylates FoxO and alters dopaminergic neuron survival in Drosophila2009

    • Author(s)
      金尾智子
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phosphorylation of FoxO by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila2009

    • Author(s)
      Imai, Y., Kanao T., Venderova, K., Park, DS., Lu, B.
    • Organizer
      第32回日本神経科学大会口演
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Phosphorylation of FoxO by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila2009

    • Author(s)
      今居譲
    • Organizer
      日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Parkinの基質としてのPael-R複合体の解析2009

    • Author(s)
      澤田知世, 今居譲, 服部信孝, 北山滋雄, 高橋良輔
    • Organizer
      第32回日本神経科学大会口演
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2011 Final Research Report
  • [Book] 「遺伝の分子基盤」ブレインサイエンス・レビュー2011

    • Author(s)
      今居譲
    • Publisher
      クバプロ社
    • Related Report
      2011 Final Research Report
  • [Book] 遺伝性パーキンソン病発症の分子基盤2011

    • Author(s)
      今居譲
    • Publisher
      クバプロ(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] 「パーキンソン病原因遺伝子研究の進展」最新医学 第65巻4号2010

    • Author(s)
      今居譲
    • Related Report
      2011 Final Research Report
  • [Book] 「遺伝性パーキンソン病原因遺伝子研究の新展開」実験医学増刊号 第28巻5号2010

    • Author(s)
      今居譲
    • Related Report
      2011 Final Research Report
  • [Book] Brain and Nerve : 遺伝性パーキンソン病研究の最前線2010

    • Author(s)
      今居譲
    • Total Pages
      11
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] 実験医学増刊号:遺伝性パーキンソン病原因遺伝子研究の新展開2010

    • Author(s)
      今居譲
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2009 Annual Research Report
  • [Book] パーキンソン病原因遺伝子研究の進展2010

    • Author(s)
      今居譲
    • Publisher
      最新医学社(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] 「遺伝性パーキンソン病研究の最前線:分子標的治療にむけて」Brain and Nerve 第61巻8号2009

    • Author(s)
      今居譲, 高橋良輔
    • Related Report
      2011 Final Research Report
  • [Remarks] 研究成果報道のウェブページ

    • URL

      http://www.tohoku.ac.jp/japanese/2010/12/press20101203-01.html

    • Related Report
      2011 Final Research Report
  • [Remarks] 研究成果報道のウェブページ

    • URL

      http://www.idac.tohoku.ac.jp/ja/frontiers/news_41/news_41a.html

    • Related Report
      2011 Final Research Report
  • [Remarks] 研究成果の報道 NHK仙台放送、日本経済新聞、河北新報、東北大学および加齢医学研究所ホームページ(2010年12月)、艮陵新聞(2012年1月)

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.tohoku.ac.jp/japanese/2010/12/press20101203-01.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.idac.tohoku.ac.jp/ja/organization/imai/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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