| Project/Area Number |
21790302
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Juntendo University (2010-2011)
Tohoku University (2009) |
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Principal Investigator |
IMAI Yuzuru 順天堂大学, 大学院・医学研究科, 先任准教授 (30321730)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | パーキンソン病 / LRRK2 / PINK1 / Parkin / 神経変性疾患 / ドーパミン神経 / ショウジョウバエ / ミトコンドリア / ドパミン神経 |
|---|
| Research Abstract |
PINK1 and LRRK2 are the genes responsible for early-onset and late-onset familial forms of Parkinson’s disease, respectively. I developed a new approach that combines a proteomics analysis and a Drosophila genetic screening to understand the pathogenesis of Parkinson’s disease caused by PINK1 and LRRK2 mutations. Using this approach, I successfully determined molecules that are involved in the PINK1 and LRRK2 pathology, which will contribute to understanding of pathogenesis in these diseases.
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