A functional analysis of HIF for tumor metastasis
| Project/Area Number |
21790304
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
YAMASHITA Toshiharu University of Tsukuba, 大学院・人間総合科学研究科, 助教 (50400677)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子腫瘍学 / 低酸素応答転写因子 / がん / がん転移 / 低酸素応答 / 血管新生 |
|---|
| Research Abstract |
VCAM-1 function was suggested that important for early metastasis foci formation. VCAM-1 expression reduced in HIF-2α knockdown mice. These results suggested that HIF-2α participate in metastasis via regulation of VCAM-1 expression. We analyzed by metastasis model in vivo. It number of the liver metastasis foci of HIF-2α kd was reduced than WT (WT : 5.0±1.0/field, HIF-2α kd : 2.8±0.76/field).
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization.2011
Author(s)
Tu TC, Kimura K, Nagano M, Yamashita T, Ohneda K, Sugimori H, Sato F, Sakakibara Y, Hamada H, Yoshikawa H, Son HN, Ohneda O.
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Journal Title
J Cell Physiol. 226(1)
Pages: 224-235
Related Report
Peer Reviewed
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[Journal Article] Identification of human placenta derived mesenchymal stem cells involved in re-endothelialization.2011
Author(s)
Tu TC, Kimura K, Nagano M, Yamashita T, Ohneda K, Sugimori H, Sato F, Sakakibara Y, Hamada H, Yoshikawa H, Son HN, Ohneda O
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Journal Title
J Cell Physiol.
Volume: Jan 226(1)
Pages: 224-235
Related Report
Peer Reviewed
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